Retrospectively gated helical cardiac computed tomographic angiography (CCTA) has been reported accurate in the evaluation of isolated valvular abnormalities, but its ability to provide comprehensive assessment of common valvular lesions is not established. We evaluated 56 consecutive patients undergoing 64-detector retrospective electrocardiogram-gated CCTA and transesophageal echocardiography for the presence of aortic and mitral stenoses, aortic and mitral regurgitations, mitral valve prolapse, and tricuspid regurgitation. Two cardiac computed tomographic angiographic readers measured maximum aortic and mitral valve opening areas, assessed for aortic or mitral valve regurgitant area, and evaluated for mitral valve prolapse. Tricuspid regurgitation was assessed by the contrast ratio of the inferior vena cava to the right heart. After excluding nondiagnostic valves on CCTA (mitral valve n = 4, aortic valve n = 2), the sensitivity, specificity, positive predictive values, and negative predictive values of CCTA compared to transesophageal echocardiography were 100%, 96%, 50%, and 100% for aortic stenosis, 44%, 96%, 67%, and 90% for aortic regurgitation, 100% each for mitral stenosis, 13%, 95%, 80%, and 45% for mitral regurgitation, and 50%, 98%, 80%, and 91% for mitral valve prolapse. There was no relation between tricuspid regurgitation grade and contrast ratio (p = 0.53). There was excellent interobserver agreement for aortic and mitral stenoses (kappa = 1.0 for each), and good agreement for aortic regurgitation, mitral regurgitation, and mitral valve prolapse (kappa = 0.81, 0.78, and 0.88, respectively). In conclusion, CCTA exhibited high diagnostic performance for detection of aortic and mitral stenoses and limited diagnostic performance for aortic regurgitation, mitral regurgitation, and mitral valve prolapse; tricuspid regurgitation could not be evaluated. The ability of CCTA to provide comprehensive assessment of valvular function is variable.