Comparison of brain glucose metabolism and monoamine oxidase B (MAO B) in traumatic brain injury

Joanna S. Fowler, Nora D. Volkow, Raphael Cilento, Gene Jack Wang, Christoph Felder, Jean Logan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: Positron emission tomography (PET) studies in patients with temporal lobe epilepsy have reported that hypometabolism in temporal regions is associated with elevated monoamine oxidase B (MAO B) probably reflecting gliosis. The purpose of this study was to examine a group of head trauma patients suffering from seizures and memory loss to determine whether hypometabolic regions show correspondingly elevated MAO B. Methods: Seven patients with traumatic brain injury received PET scans with 18FDG and [11C] L - deprenyl-D2 to measure regional glucose metabolism (LCMRglu) and MAO B respectively. Results were compared to a group of nine age-matched healthy controls. Hypometabolic regions were identified and MAO B values corresponding to these brain regions were determined. Averaged brain images for temporal regions for LCMRglu and MAO were also compared. Results: LCMRglu values for temporal regions were reduced in patients relative to normal subjects. Of the 13 hypometabolic brain regions, 6 (46%) showed a corresponding elevation in MAO B. There was a trend for a significant inverse relationship between normalized LCMRglu and normalized MAO B values for medial temporal cortex. Glucose metabolism was significantly higher in lateral than medial temporal regions whereas the pattern was reversed for MAO B. Conclusion: MAO B images provide a markedly better delineation of the medial temporal regions than LCMRglu. There was not a consistent inverse relationship between metabolism and MAO B as had been reported in PET studies of epileptogenic temporal lobes with [11C] L -deprenyl-D2 and 18FDG indicating that prospective studies are needed to determine the pathophysiology of hypometabolic lesions in head trauma.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalClinical Positron Imaging (Netherlands)
Volume2
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Glucose Metabolism
  • Monoamine Oxidase B (MAO B)
  • Traumatic Brain Injury

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