Fifty patients with coronary artery disease were studied with biplane left cineventriculography (right and left anterior oblique views). Volumetric analyses were compared with those of 10 normal patients also studied with simultaneous biplane ventriculography. In normal subjects there was good agreement between minor diameters in the right and left anterior oblique views, and between ventricular volumes and ejection fractions determined by single plane and biplane techniques. In patients with coronary artery disease there was more scatter in these values, especially when asynergy was present. Loss of ventricular symmetry probably explains this disparity. By providing visualization of all five zones of the left ventricular wall, the biplane technique allowed a comprehensive evaluation of ventricular asynergy and overall function. The clinical profile of the 50 patients with coronary artery disease demonstrated that optimal candidates for biplane ventriculography are patients with prior myocardial infarction, left ventricular enlargement and clinical evidence of abnormal hemodynamic status.