Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses

B. Fiszon; C. Hannoun; A. Garcia-Sastre; E. Villar; J. A. Cabezas

doi:10.1016/S0923-2516(89)80118-9

Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses

B. Fiszon
, C. Hannoun
, A. Garcia-Sastre
, E. Villar
, J. A. Cabezas

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40°C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.

Original language	English
Pages (from-to)	395-404
Number of pages	10
Journal	Research in Virology
Volume	140
Issue number	C
DOIs	https://doi.org/10.1016/S0923-2516(89)80118-9
State	Published - 1989
Externally published	Yes

Keywords

A(H1N1) subtype
Birds
Influenza virus
Mammals
Orthomyxovirus
Physicochemical criteria

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10.1016/S0923-2516(89)80118-9

Cite this

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title = "Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses",

abstract = "The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40°C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.",

keywords = "A(H1N1) subtype, Birds, Influenza virus, Mammals, Orthomyxovirus, Physicochemical criteria",

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TY - JOUR

T1 - Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses

AU - Fiszon, B.

AU - Hannoun, C.

AU - Garcia-Sastre, A.

AU - Villar, E.

AU - Cabezas, J. A.

PY - 1989

Y1 - 1989

N2 - The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40°C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.

AB - The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40°C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.

KW - A(H1N1) subtype

KW - Birds

KW - Influenza virus

KW - Mammals

KW - Orthomyxovirus

KW - Physicochemical criteria

UR - https://www.scopus.com/pages/publications/0024357825

U2 - 10.1016/S0923-2516(89)80118-9

DO - 10.1016/S0923-2516(89)80118-9

M3 - Article

C2 - 2587848

AN - SCOPUS:0024357825

SN - 0923-2516

VL - 140

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EP - 404

JO - Research in Virology

JF - Research in Virology

IS - C

ER -

Comparison of biological and physical properties of human and animal A(H1N1) influenza viruses

Abstract

Keywords

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