Comparison of biexponential and monoexponential model of diffusion weighted imaging in evaluation of renal lesions: Preliminary experience

Hersh Chandarana, Vivian S. Lee, Elizabeth Hecht, Bachir Taouli, Eric E. Sigmund

Research output: Contribution to journalArticlepeer-review

176 Scopus citations


Objectives: To obtain intravoxel incoherent motion (IVIM) parameters with biexponential analysis of multiple b-value diffusion-weighted imaging (DWI) and compare these parameters to apparent diffusion coefficient (ADC) obtained with monoexponential modeling in their ability to discriminate enhancing from nonenhancing renal lesions. Materials and methods: Twenty-eight patients were imaged at 1.5 T utilizing contrast-enhanced (CE) magnetic resonance imaging (MRI) and breath-hold DWI using 8 b values (range: 0-800 s/mm). Perfusion fraction (fp), tissue diffusivity (Dt), and pseudo-diffusion coefficient (Dp) were calculated using segmented biexponential analysis. ADCtotal and ADC0-400-800 were calculated with monoexponential fitting of the DWI data. fp, Dt, Dp, ADCtotal, and ADC0-400-800 were compared between enhancing and nonenhancing renal lesions. Receiver operating characteristic analysis was performed for all DWI parameters. fp was correlated with percent enhancement. Results: There were a total of 31 renal lesions (15 enhancing and 16 nonenhancing) in 28 patients on CE-MRI. fp of enhancing masses was significantly higher (27.9 vs. 6.1) and Dt was significantly lower (1.47 vs. 2.40 ×10 mm/s). IVIM parameters fp and Dt demonstrated higher accuracy in differentiating enhancing from nonenhancing renal lesions compared with monoexponential parameters ADC0-400-800 and ADCtotal, with area under the curve of 0.946, 0.896, 0.854, and 0.675, respectively. There was a good correlation between fp and percent enhancement (r = 0.7; P < 0.001). Conclusion: IVIM parameters fp and Dt obtained with biexponential fitting of multi-b value DWI have higher accuracy compared with ADC (obtained with monoexponential fit) in discriminating enhancing from nonenhancing renal lesions. Furthermore, fp demonstrates good correlation with percent enhancement and can provide information regarding lesion vascularity without the use of exogenous contrast agent.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalInvestigative Radiology
Issue number5
StatePublished - May 2011


  • diffusion weighted imaging (DWI)
  • intravoxel incoherent motion (IVIM)
  • renal cancer
  • renal mass


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