Comparison of apoptosis and terminal differentiation: The mammalian aging process

C. E. Gagna; H. R. Kuo; E. Florea; W. Shami; R. Taormina; N. Vaswani; M. Gupta; R. Vijh; W. C. Lambert

doi:10.1177/002215540104900717

Comparison of apoptosis and terminal differentiation: The mammalian aging process

C. E. Gagna, H. R. Kuo, E. Florea, W. Shami, R. Taormina, N. Vaswani, M. Gupta, R. Vijh, W. C. Lambert

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death.

Original language	English
Pages (from-to)	929-930
Number of pages	2
Journal	Journal of Histochemistry and Cytochemistry
Volume	49
Issue number	7
DOIs	https://doi.org/10.1177/002215540104900717
State	Published - 2001
Externally published	Yes

Keywords

Apoptosis
B-DNA
Denatured DNA
Terminal differentiation
Z-DNA

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title = "Comparison of apoptosis and terminal differentiation: The mammalian aging process",

abstract = "Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death.",

keywords = "Apoptosis, B-DNA, Denatured DNA, Terminal differentiation, Z-DNA",

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TY - JOUR

T1 - Comparison of apoptosis and terminal differentiation

T2 - The mammalian aging process

AU - Gagna, C. E.

AU - Kuo, H. R.

AU - Florea, E.

AU - Shami, W.

AU - Taormina, R.

AU - Vaswani, N.

AU - Gupta, M.

AU - Vijh, R.

AU - Lambert, W. C.

PY - 2001

Y1 - 2001

N2 - Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death.

AB - Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death.

KW - Apoptosis

KW - B-DNA

KW - Denatured DNA

KW - Terminal differentiation

KW - Z-DNA

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JO - Journal of Histochemistry and Cytochemistry

JF - Journal of Histochemistry and Cytochemistry

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Comparison of apoptosis and terminal differentiation: The mammalian aging process

Abstract

Keywords

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