Comparison of antipsychotic naïve first-episode psychosis patients and healthy controls in Uganda

Emmanuel K. Mwesiga, Dickens Akena, Nastassja Koen, Juliet Nakku, Noeline Nakasujja, Dan J. Stein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: The risk factors for a first episode of psychosis in low and middle-income countries (LMICs) are not well described. The study compared the association of different risk factors in patients with first-episode psychosis patients and healthy controls from an LMIC context. Methods: A comparative, descriptive, cross-sectional study was performed in antipsychotic naïve first-episode psychosis patients and healthy controls at the National referral hospital in Uganda. Standardized tools were used to assess sociodemographic (e.g., age, sex, socioeconomic status) and clinical (e.g., childhood trauma, quality of life) variables. First episode psychosis participants were compared to healthy controls in terms of sociodemographic and clinical variables, and logistic regression was used to determine predictors of FEP. Results: Our final sample included 198 antipsychotic naïve first-episode psychosis participants and 82 controls. Most participants were female (68.5%) with a mean age of 29.4 years. After adjusting for age and sex, FEP patients when compared to controls were less likely to be female [AOR 0.18 (95%CI 0.03–0.85; p =.031)], more likely to have experienced emotional abuse [AOR 1.30 (95%CI 1.02–1.65; p =.032)] and more likely to have a poor quality of life [AOR 0.93 (95%CI 0.89–0.97; p =.002)]. Discussion: The risk factors for a first episode of psychosis in this low and middle-income population were like those described in high-income countries. Further studies on interventions to prevent the transition to psychotic disorders in this sub-groups of patients are recommended. Also, the use of specialized early intervention services in improving the quality of life needs to be evaluated.

Original languageEnglish
Pages (from-to)1713-1720
Number of pages8
JournalEarly Intervention in Psychiatry
Volume15
Issue number6
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • affective psychosis
  • first episode psychosis
  • non-affective psychosis

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