Comparison of Angiographic and Intravascular Ultrasonic Detection of Myocardial Bridging of the Left Anterior Descending Coronary Artery

Kenichi Tsujita, Akiko Maehara, Gary S. Mintz, Hiroshi Doi, Takashi Kubo, Celia Castellanos, Jian Liu, Junqing Yang, Carlos Oviedo, Theresa Franklin-Bond, Neil Dasgupta, Sinan Biro, Lokesh Dani, George D. Dangas, Roxana Mehran, Ajay J. Kirtane, Alexandra J. Lansky, Edward M. Kreps, Michael B. Collins, Gregg W. StoneJeffrey W. Moses, Martin B. Leon

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The purpose of this study was to determine the incidence, location, and clinical features of myocardial bridging (MB) detected by intravascular ultrasound (IVUS) and to compare IVUS-detectable versus angiographically detectable MBs. IVUS images were analyzed in 331 consecutive patients with de novo coronary lesions located in the left anterior descending coronary artery (LAD). MB was defined as a segment of coronary artery having systolic compression and echocardiographically lucent muscle surrounding the artery (IVUS) or systolic milking (angiography). Although angiography detected MB in only 3% of patients (11 of 331), 75 MB segments (23%, 75 of 331, p <0.001) were identified by IVUS. Maximum plaque burden within the MB segment measured only 25 ± 7%, and abnormal intimal thickness (defined as ≥0.5 mm) was not observed within the bridged segment of any patient with MB, although the study population had advanced atherosclerosis. Vessel and lumen areas in the MB segment were significantly smaller than those in adjacent proximal and even distal reference segments. Angiographically detectable MB was significantly longer, located more proximally in the LAD, and had more severe systolic compression by IVUS. Angiographically silent MB more often occurred in the presence of an adjacent proximal stenosis and lower left ventricular ejection fraction. In conclusion, IVUS may provide useful anatomic information for the accurate diagnosis of MBs that are largely angiographically silent. IVUS-detectable MBs were observed in approximately frac(1, 4) of patients undergoing LAD imaging at our center.

Original languageEnglish
Pages (from-to)1608-1613
Number of pages6
JournalAmerican Journal of Cardiology
Issue number12
StatePublished - 15 Dec 2008
Externally publishedYes


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