TY - JOUR
T1 - Comparative study of piperacillin, ticarcillin, and carbenicillin pharmacokinetics
AU - Meyers, B. R.
AU - Hirschman, S. Z.
AU - Strougo, L.
AU - Srulevitch, E.
PY - 1980
Y1 - 1980
N2 - Piperacillin, ticarcillin, and carbenicillin were administered intravenously to 10 healthy volunteers in a three-way, crossover study. The pharmacokinetics of the three drugs were in general quite similar. The peak serum concentration of piperacillin achieved at the end of a 30-min intravenous infusion was 63.5 ± 27.6 μg/ml. During the first 8 h, 67.5% of the dose of piperacillin was excreted in the urine, and the urinary concentration was extremely high. All three penicillins had high volumes of distribution. The serum half-life of the beta elimination phase of carbenicillin was lower than that of either piperacillin or ticarcillin. The volunteers experienced no adverse reactions from the administration of the drugs.
AB - Piperacillin, ticarcillin, and carbenicillin were administered intravenously to 10 healthy volunteers in a three-way, crossover study. The pharmacokinetics of the three drugs were in general quite similar. The peak serum concentration of piperacillin achieved at the end of a 30-min intravenous infusion was 63.5 ± 27.6 μg/ml. During the first 8 h, 67.5% of the dose of piperacillin was excreted in the urine, and the urinary concentration was extremely high. All three penicillins had high volumes of distribution. The serum half-life of the beta elimination phase of carbenicillin was lower than that of either piperacillin or ticarcillin. The volunteers experienced no adverse reactions from the administration of the drugs.
UR - https://www.scopus.com/pages/publications/0018906909
U2 - 10.1128/AAC.17.4.608
DO - 10.1128/AAC.17.4.608
M3 - Article
C2 - 6446878
AN - SCOPUS:0018906909
SN - 0066-4804
VL - 17
SP - 608
EP - 611
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -