TY - JOUR
T1 - Comparative study of commercial food antigen extracts for the diagnosis of food hypersensitivity
AU - Sampson, Hugh A.
N1 - Funding Information:
From the Division of Immunology. Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Md. Supported by Grants No. AI24439 and AI00830 from the National Institute of Allergy and Infectious Diseases and by Grant No. RR-30 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. Received for publication July 30, 1987. Accepted for publication April 17, 1988. Reprint requests: Dr. Hugh A. Sampson, MD, Associate Professor of Pediatrics, Division of Immunology, Department of Pediatrics, The John Hopkins University School of Medicine, Baltimore, MD 21205. *Recipient of the Allergic Diseases Academic Award of the National Institutes of Health.
PY - 1988/11
Y1 - 1988/11
N2 - Single lots of food allergen extracts from three different commercial sources were compared for their efficacy in evaluating immediate food hypersensitivity. Eighty-seven children with atopic dermatitis and food hypersensitivity underwent prick skin testing to a battery of 18 food extracts from each company. Results of skin tests were compared with results of double-blind, placebo-controlled oral food challenges and open challenges to determine the sensitivity, specificity, and predictive indices of each reagent. Negative predictive indices were generally good for all reagents, whereas positive predictive indices were generally poor and showed considerable variation (0% to 79%) between commercial sources. Under the conditions of the study, skin test reagents from two companies showed slightly better agreement with double-blind, placebo-controlled food challenge results than did reagents from the third company. However, with known lot-to-lot variations in extract potency and intrapatient variation in skin test results, these differences probably are not of clinical significance.
AB - Single lots of food allergen extracts from three different commercial sources were compared for their efficacy in evaluating immediate food hypersensitivity. Eighty-seven children with atopic dermatitis and food hypersensitivity underwent prick skin testing to a battery of 18 food extracts from each company. Results of skin tests were compared with results of double-blind, placebo-controlled oral food challenges and open challenges to determine the sensitivity, specificity, and predictive indices of each reagent. Negative predictive indices were generally good for all reagents, whereas positive predictive indices were generally poor and showed considerable variation (0% to 79%) between commercial sources. Under the conditions of the study, skin test reagents from two companies showed slightly better agreement with double-blind, placebo-controlled food challenge results than did reagents from the third company. However, with known lot-to-lot variations in extract potency and intrapatient variation in skin test results, these differences probably are not of clinical significance.
UR - http://www.scopus.com/inward/record.url?scp=0024235849&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(88)90070-X
DO - 10.1016/0091-6749(88)90070-X
M3 - Article
C2 - 2461401
AN - SCOPUS:0024235849
SN - 0091-6749
VL - 82
SP - 718
EP - 726
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 5 PART 1
ER -