Comparative neurotoxicity of angiographic contrast media

Richard Velaj, Burton Drayer, Robert Albright, Evan Fram

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The neurotoxic effects in cerebral angiography of three iodinated ionic contrast media, nonionic iopamidol, 25% mannitol, and saline controls were compared in 25 rabbits. Diatrizoate sodium meglumine was the most toxic agent, followed by diatrizoate meglumine, iothalamate meglumine, and mannitol in terms of blood-brain barrier (BBB) disruption and coupled perfusion decline. HIPDm distribution was more sensitive than trypan blue extravasation for monitoring brain dysfunction. Iopamidol and saline controls exhibited no visual BBB breakdown or alteration in regional uptake of 1-125 HIPDm, confirming the safety of nonionic iopamidol as compared with presently used ionic contrast media.

Original languageEnglish
Pages (from-to)1290-1298
Number of pages9
JournalNeurology
Volume35
Issue number9
DOIs
StatePublished - Sep 1985
Externally publishedYes

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