TY - JOUR
T1 - Comparative mapping of host-pathogen protein-protein interactions
AU - Shah, Priya S.
AU - Wojcechowskyj, Jason A.
AU - Eckhardt, Manon
AU - Krogan, Nevan J.
N1 - Funding Information:
We would like to acknowledge Mike Shales, Ruth Hüttenhain, Erik Verschueren, Judd Hultquist and Joshua Kane for critical reading of the manuscript. Funding was provided by NIAID AI112262 to PSS, NIAID AI116410 to JAW and P50 GM082250 , P01 AI090935 , P50 GM081879 , P01 AI091575 , DARPA-10-93-Prophecy-PA-008 , R01 DA033773 , P01 HL089707 , U19 AI106754 , R01 GM084279 and P01 CA177322-01A1 to NJK.
Publisher Copyright:
© 2015 Published by Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.
AB - Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.
UR - http://www.scopus.com/inward/record.url?scp=84939122802&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2015.07.008
DO - 10.1016/j.mib.2015.07.008
M3 - Review article
C2 - 26275922
AN - SCOPUS:84939122802
VL - 27
SP - 62
EP - 68
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
ER -