Comparative immunological studies of RNA C-type viruses: Radioimmunoassay for a low molecular weight polypeptide of woolly monkey leukemia virus

Steven R. Tronick; John R. Stephenson; Stuart A. Aaronson

doi:10.1016/0042-6822(74)90174-3

Comparative immunological studies of RNA C-type viruses: Radioimmunoassay for a low molecular weight polypeptide of woolly monkey leukemia virus

Steven R. Tronick, John R. Stephenson, Stuart A. Aaronson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A 12,000-dalton polypeptide was partially purified from the woolly monkey RNA C-type virus. A sensitive and specific radioimmunoassay for this polypeptide detected major differences in the reactivities of woolly monkey and gibbon ape viruses. In contrast, these viruses were indistinguishable in immunoassays for two other woolly monkey virion proteins, the major structural polypeptide and the reverse transcriptase. Each assay readily differentiated the woolly and gibbon from other mammalian RNA C-type viruses.

Original language	English
Pages (from-to)	347-356
Number of pages	10
Journal	Virology
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(74)90174-3
State	Published - Feb 1974
Externally published	Yes

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title = "Comparative immunological studies of RNA C-type viruses: Radioimmunoassay for a low molecular weight polypeptide of woolly monkey leukemia virus",

abstract = "A 12,000-dalton polypeptide was partially purified from the woolly monkey RNA C-type virus. A sensitive and specific radioimmunoassay for this polypeptide detected major differences in the reactivities of woolly monkey and gibbon ape viruses. In contrast, these viruses were indistinguishable in immunoassays for two other woolly monkey virion proteins, the major structural polypeptide and the reverse transcriptase. Each assay readily differentiated the woolly and gibbon from other mammalian RNA C-type viruses.",

author = "Tronick, {Steven R.} and Stephenson, {John R.} and Aaronson, {Stuart A.}",

note = "Funding Information: We thank Patricia S. Leake, Joan A. Brayton, and Roberta K. Reynolds for expert technical assistance. This work was supported by Contract No. NIH-NCI-E-73-3212 of the Cancer Virus Program of t,he National Cancer Institute.",

year = "1974",

month = feb,

doi = "10.1016/0042-6822(74)90174-3",

language = "English",

volume = "57",

pages = "347--356",

journal = "Virology",

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T1 - Comparative immunological studies of RNA C-type viruses

T2 - Radioimmunoassay for a low molecular weight polypeptide of woolly monkey leukemia virus

AU - Tronick, Steven R.

AU - Stephenson, John R.

AU - Aaronson, Stuart A.

N1 - Funding Information: We thank Patricia S. Leake, Joan A. Brayton, and Roberta K. Reynolds for expert technical assistance. This work was supported by Contract No. NIH-NCI-E-73-3212 of the Cancer Virus Program of t,he National Cancer Institute.

PY - 1974/2

Y1 - 1974/2

N2 - A 12,000-dalton polypeptide was partially purified from the woolly monkey RNA C-type virus. A sensitive and specific radioimmunoassay for this polypeptide detected major differences in the reactivities of woolly monkey and gibbon ape viruses. In contrast, these viruses were indistinguishable in immunoassays for two other woolly monkey virion proteins, the major structural polypeptide and the reverse transcriptase. Each assay readily differentiated the woolly and gibbon from other mammalian RNA C-type viruses.

AB - A 12,000-dalton polypeptide was partially purified from the woolly monkey RNA C-type virus. A sensitive and specific radioimmunoassay for this polypeptide detected major differences in the reactivities of woolly monkey and gibbon ape viruses. In contrast, these viruses were indistinguishable in immunoassays for two other woolly monkey virion proteins, the major structural polypeptide and the reverse transcriptase. Each assay readily differentiated the woolly and gibbon from other mammalian RNA C-type viruses.

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AN - SCOPUS:0015980225

SN - 0042-6822

VL - 57

SP - 347

EP - 356

JO - Virology

JF - Virology

IS - 2

ER -

Comparative immunological studies of RNA C-type viruses: Radioimmunoassay for a low molecular weight polypeptide of woolly monkey leukemia virus

Abstract

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