Comparative effects of valsartan plus cilnidipine or hydrochlorothiazide on nocturnal home blood pressure

Takeshi Fujiwara, Satoshi Hoshide, Naoko Tomitani, Hiroshi Kanegae, Kazuomi Kario

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We tested our hypothesis that, in hypertensive patients with higher nocturnal home systolic blood pressure (HSBP) at baseline, a valsartan/cilnidipine (80/10 mg) combination would reduce nocturnal HSBP more markedly than a valsartan/hydrochlorothiazide (80/12.5 mg) combination. Patients measured their nocturnal HSBP over three nights prior to study randomization and at the end of treatment. Sixty-three and 66 patients comprised the valsartan/cilnidipine and valsartan/hydrochlorothiazide groups; their respective baseline nocturnal HSBP values were 124.3 ± 15.6 and 125.8 ± 15.2 mm Hg (P =.597). Nocturnal HSBPs were significantly reduced from baseline in both groups. Although the valsartan/hydrochlorothiazide group exhibited a significantly greater reduction in nocturnal HSBP compared to the valsartan/cilnidipine group (−5.0 vs. −10.0 mm Hg, P =.035), interaction between the treatment groups and the baseline nocturnal HSBP levels for the changes in nocturnal HSBP after the treatment periods was significant (P =.047). The BP-lowering effect of valsartan/cilnidipine was more dependent on baseline nocturnal HSBP than that of valsartan/hydrochlorothiazide.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalJournal of Clinical Hypertension
Issue number3
StatePublished - Mar 2021
Externally publishedYes


  • automatic ICT-based home blood pressure monitoring device
  • morning blood pressure
  • nocturnal home blood pressure
  • valsartan/cilnidipine combination
  • valsartan/hydrochlorothiazide combination


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