TY - JOUR
T1 - Comorbidity and healthcare utilization in patients with treatment resistant depression
T2 - A large-scale retrospective cohort analysis using electronic health records
AU - Adekkanattu, Prakash
AU - Olfson, Mark
AU - Susser, Leah C.
AU - Patra, Braja
AU - Vekaria, Veer
AU - Coombes, Brandon J.
AU - Lepow, Lauren
AU - Fennessy, Brian
AU - Charney, Alexander
AU - Ryu, Euijung
AU - Miller, Kurt D.
AU - Pan, Lifang
AU - Yangchen, Tenzin
AU - Talati, Ardesheer
AU - Wickramaratne, Priya
AU - Weissman, Myrna
AU - Mann, John
AU - Biernacka, Joanna M.
AU - Pathak, Jyotishman
N1 - Funding Information:
This study was supported by the National Institute of Mental Health (NIMH) grants: R01MH121922 , R01MH121924 , R01MH121923 , and R01MH121921 .
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Background: Medical comorbidity and healthcare utilization in patients with treatment resistant depression (TRD) is usually reported in convenience samples, making estimates unreliable. There is only limited large-scale clinical research on comorbidities and healthcare utilization in TRD patients. Methods: Electronic Health Record data from over 3.3 million patients from the INSIGHT Clinical Research Network in New York City was used to define TRD as initiation of a third antidepressant regimen in a 12-month period among patients diagnosed with major depressive disorder (MDD). Age and sex matched TRD and non-TRD MDD patients were compared for anxiety disorder, 27 comorbid medical conditions, and healthcare utilization. Results: Out of 30,218 individuals diagnosed with MDD, 15.2 % of patients met the criteria for TRD (n = 4605). Compared to MDD patients without TRD, the TRD patients had higher rates of anxiety disorder and physical comorbidities. They also had higher odds of ischemic heart disease (OR = 1.38), stroke/transient ischemic attack (OR = 1.57), chronic kidney diseases (OR = 1.53), arthritis (OR = 1.52), hip/pelvic fractures (OR = 2.14), and cancers (OR = 1.41). As compared to non-TRD MDD, TRD patients had higher rates of emergency room visits, and inpatient stays. In relation to patients without MDD, both TRD and non-TRD MDD patients had significantly higher levels of anxiety disorder and physical comorbidities. Limitations: The INSIGHT-CRN data lack information on depression severity and medication adherence. Conclusions: TRD patients compared to non-TRD MDD patients have a substantially higher prevalence of various psychiatric and medical comorbidities and higher health care utilization. These findings highlight the challenges of developing interventions and care coordination strategies to meet the complex clinical needs of TRD patients.
AB - Background: Medical comorbidity and healthcare utilization in patients with treatment resistant depression (TRD) is usually reported in convenience samples, making estimates unreliable. There is only limited large-scale clinical research on comorbidities and healthcare utilization in TRD patients. Methods: Electronic Health Record data from over 3.3 million patients from the INSIGHT Clinical Research Network in New York City was used to define TRD as initiation of a third antidepressant regimen in a 12-month period among patients diagnosed with major depressive disorder (MDD). Age and sex matched TRD and non-TRD MDD patients were compared for anxiety disorder, 27 comorbid medical conditions, and healthcare utilization. Results: Out of 30,218 individuals diagnosed with MDD, 15.2 % of patients met the criteria for TRD (n = 4605). Compared to MDD patients without TRD, the TRD patients had higher rates of anxiety disorder and physical comorbidities. They also had higher odds of ischemic heart disease (OR = 1.38), stroke/transient ischemic attack (OR = 1.57), chronic kidney diseases (OR = 1.53), arthritis (OR = 1.52), hip/pelvic fractures (OR = 2.14), and cancers (OR = 1.41). As compared to non-TRD MDD, TRD patients had higher rates of emergency room visits, and inpatient stays. In relation to patients without MDD, both TRD and non-TRD MDD patients had significantly higher levels of anxiety disorder and physical comorbidities. Limitations: The INSIGHT-CRN data lack information on depression severity and medication adherence. Conclusions: TRD patients compared to non-TRD MDD patients have a substantially higher prevalence of various psychiatric and medical comorbidities and higher health care utilization. These findings highlight the challenges of developing interventions and care coordination strategies to meet the complex clinical needs of TRD patients.
KW - Electronic health records
KW - Healthcare utilization
KW - Major depressive disorder
KW - Medical comorbidities
KW - Treatment resistant depression
UR - http://www.scopus.com/inward/record.url?scp=85145295723&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2022.12.044
DO - 10.1016/j.jad.2022.12.044
M3 - Article
C2 - 36529406
AN - SCOPUS:85145295723
SN - 0165-0327
VL - 324
SP - 102
EP - 113
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -