Comorbidities of atopic dermatitis—what does the evidence say?

Jacob P. Thyssen, Anne Sofie Halling, Peter Schmid-Grendelmeier, Emma Guttman-Yassky, Jonathan I. Silverberg

Research output: Contribution to journalReview articlepeer-review


Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic comorbidities. There has been a growing interest in this area of AD, because presence or risk of comorbidities can in many ways impact the management of patients with AD. Thus, some treatments for AD may improve its comorbidities as well, whereas others may increase their risk. In this review article, we discuss various comorbidities of AD mostly on the basis of the results of recent multiple systematic reviews and meta-analyses to update readers about this rapidly developing area of dermatology. We emphasize the important information provided by studies presenting both relative risk and absolute risk, and show that AD is associated with, among others, atopic comorbidities such as asthma, rhinitis, and food allergy, nonatopic comorbidities such as ocular, psychiatric, infectious, endocrine, autoimmune, and cardiovascular diseases, and certain cancers. Clinicians need to be aware of these and be cognizant about positive and negative effects of existing and new treatments for AD.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
StateAccepted/In press - 2023


  • Atopic dermatitis
  • asthma
  • atopy
  • burden
  • comorbidity
  • epidemiology


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