TY - JOUR
T1 - Community-acquired pneumonia during the first post-pandemic influenza season
T2 - A prospective, multicentre cohort study
AU - Viasus, Diego
AU - Marinescu, Carmen
AU - Villoslada, Aroa
AU - Cordero, Elisa
AU - Gálvez-Acebal, Juan
AU - Fariñas, María C.
AU - Gracia-Ahufinger, Irene
AU - Fernández-Navarro, Anabel
AU - Niubó, Jordi
AU - Ortega, Lucia
AU - Muñez-Rubio, Elena
AU - Romero-Gómez, María P.
AU - Carratalà, Jordi
AU - Riera, Melchor
AU - Payeras, Antoni
AU - Férnandez-Baca, Victoria
AU - Gutiérrez, Antonio
AU - Aydillo, Teresa
AU - Sánchez, Agdalena
AU - Osorio, Giovana
AU - Milara, Caridad
AU - Perez-Romero, Pilar
AU - Pachón, Jerónimo
AU - Fernández-Cuenca, Felipe
AU - Rodríguez-Baño, Jesús
AU - Ruiz, Carmen Casillas
AU - De la Fuente, Celia García
AU - Sanjuán, María Victoria
AU - Parra, José Antonio
AU - Torre-Cisneros, Julián
AU - Casal, Manuel
AU - Causse, Manuel
AU - Gutiérrez-Aroca, Juan
AU - Lara, Rosario
AU - Rivero, Antonio
AU - Rodríguez, Fernando
AU - Tejero, Rocio
AU - Martínez-Montauti, Joaquín
AU - Azorín, Francisca Portero
AU - Martínez, Antonio Ramos
AU - Álvarez-Espejo Montiel, Teresa
AU - Caro-Bragado, Sarah
AU - Paño-Pardo, José Ramón
N1 - Funding Information:
This research was supported by the Ministerio de Ciencia e Innovación , Instituto de Salud Carlos III , Programa de Investigación sobre gripe A/H1N1 ( GR09/0014 ). It was co-financed by Ministerio de Economía y Competitividad, Instituto de Salud Carlos III – co-financed by European Development Regional Fund "A way to achieve Europe" ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015). DV is the recipient of a research grant from the REIPI.
PY - 2013/9
Y1 - 2013/9
N2 - Objectives: To determine the aetiology, clinical features and prognosis of CAP during the first post-pandemic influenza season. We also assessed the factors associated with severe disease and tested the ability of a scoring system for identifying influenza A (H1N1)pdm09-related pneumonia. Methods: Prospective cohort study carried out at 10 tertiary hospitals of Spain. All adults hospitalised with CAP from December 01, 2010 to March 31, 2011 were analysed. Results: A total of 747 adults with CAP required hospitalisation. The aetiology was determined in 315 (42.2%) patients, in whom 154 (21.9%) were due to bacteria, 125 (16.7%) were due to viruses and 36 (4.8%) were mixed (due to viruses and bacteria). The most frequently isolated bacteria were Streptococccus pneumoniae. Among patients with viral pneumonia, the most common organism identified were influenza A (H1N1)pdm09. Independent factors associated with severe disease were impaired consciousness, septic shock, tachypnea, hyponatremia, hypoxemia, influenza B, and influenza A (H1N1)pdm09. The scoring system evaluated did not differentiate reliably between patients with influenza A (H1N1)pdm09-related pneumonia and those with other aetiologies. Conclusions: The frequency of bacterial and viral pneumonia during the first post-pandemic influenza season was similar. The main identified virus was influenza A (H1N1)pdm09, which was associated with severe disease. Although certain presenting clinical features may allow recognition of influenza A (H1N1)pdm09-related pneumonia, it is difficult to express them in a reliable scoring system.
AB - Objectives: To determine the aetiology, clinical features and prognosis of CAP during the first post-pandemic influenza season. We also assessed the factors associated with severe disease and tested the ability of a scoring system for identifying influenza A (H1N1)pdm09-related pneumonia. Methods: Prospective cohort study carried out at 10 tertiary hospitals of Spain. All adults hospitalised with CAP from December 01, 2010 to March 31, 2011 were analysed. Results: A total of 747 adults with CAP required hospitalisation. The aetiology was determined in 315 (42.2%) patients, in whom 154 (21.9%) were due to bacteria, 125 (16.7%) were due to viruses and 36 (4.8%) were mixed (due to viruses and bacteria). The most frequently isolated bacteria were Streptococccus pneumoniae. Among patients with viral pneumonia, the most common organism identified were influenza A (H1N1)pdm09. Independent factors associated with severe disease were impaired consciousness, septic shock, tachypnea, hyponatremia, hypoxemia, influenza B, and influenza A (H1N1)pdm09. The scoring system evaluated did not differentiate reliably between patients with influenza A (H1N1)pdm09-related pneumonia and those with other aetiologies. Conclusions: The frequency of bacterial and viral pneumonia during the first post-pandemic influenza season was similar. The main identified virus was influenza A (H1N1)pdm09, which was associated with severe disease. Although certain presenting clinical features may allow recognition of influenza A (H1N1)pdm09-related pneumonia, it is difficult to express them in a reliable scoring system.
KW - Clinical features
KW - Community-acquired pneumonia
KW - Influenza A (H1N1)pdm09
KW - Mortality
KW - Post-pandemic period
UR - https://www.scopus.com/pages/publications/84881027197
U2 - 10.1016/j.jinf.2013.05.006
DO - 10.1016/j.jinf.2013.05.006
M3 - Article
C2 - 23747416
AN - SCOPUS:84881027197
SN - 0163-4453
VL - 67
SP - 185
EP - 193
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -