@article{60abd758c8bc423daae2f0fe0964f4f0,
title = "CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder",
abstract = "Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which risk alleles with small effects lead to schizophrenia and bipolar disorder. In order to fill this gap between genetics and disease phenotype, we have undertaken a multi-cohort genomics study of postmortem brains from controls, individuals with schizophrenia and bipolar disorder. Here we present a public resource of functional genomic data from the dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) of 986 individuals from 4 separate brain banks, including 353 diagnosed with schizophrenia and 120 with bipolar disorder. The genomic data include RNA-seq and SNP genotypes on 980 individuals, and ATAC-seq on 269 individuals, of which 264 are a subset of individuals with RNA-seq. We have performed extensive preprocessing and quality control on these data so that the research community can take advantage of this public resource available on the Synapse platform at http://CommonMind.org.",
author = "Hoffman, {Gabriel E.} and Jaroslav Bendl and Georgios Voloudakis and Montgomery, {Kelsey S.} and Laura Sloofman and Wang, {Ying Chih} and Shah, {Hardik R.} and Hauberg, {Mads E.} and Johnson, {Jessica S.} and Kiran Girdhar and Lingyun Song and Fullard, {John F.} and Robin Kramer and Hahn, {Chang Gyu} and Raquel Gur and Stefano Marenco and Lipska, {Barbara K.} and Lewis, {David A.} and Vahram Haroutunian and Scott Hemby and Patrick Sullivan and Schahram Akbarian and Andrew Chess and Buxbaum, {Joseph D.} and Crawford, {Greg E.} and Enrico Domenici and Bernie Devlin and Sieberts, {Solveig K.} and Peters, {Mette A.} and Panos Roussos",
note = "Funding Information: We thank the patients and families who donated material for these studies. We thank T. Lehner for his early and inspirational ideas about this project, as well as organizational and intellectual support. Data were generated as part of the CommonMind Consortium supported by funding from Takeda Pharmaceuticals Company Limited, F. Hoffmann-La Roche Ltd and NIH grants U01MH116442, R01MH085542, R01MH093725, P50MH066392, P50MH080405, R01MH097276, RO1-MH-075916, P50M096891, P50MH084053S1, R37MH057881, AG02219, AG05138, MH06692, R01MH110921, R01MH109677, R01MH109897, U01MH103392, and contract HHSN271201300031C through IRP NIMH. Brain tissue for the study was obtained from the following brain bank collections: the Mount Sinai NIH Brain and Tissue Repository, the University of Pennsylvania Alzheimer{\textquoteright}s Disease Core Center, the University of Pittsburgh NeuroBioBank and Brain and Tissue Repositories, and the NIMH Human Brain Collection Core. CMC Leadership: Panos Roussos, Joseph Buxbaum, Andrew Chess, Schahram Akbarian, Vahram Haroutunian (Icahn School of Medicine at Mount Sinai), Bernie Devlin, David Lewis (University of Pittsburgh), Raquel Gur, Chang-Gyu Hahn (University of Pennsylvania), Enrico Domenici (University of Trento), Mette A. Peters, Solveig Sieberts (Sage Bionetworks), Thomas Lehner, Stefano Marenco, Barbara K. Lipska (NIMH). Rhesus Macaque tissue was provided by Scott Hemby through the Stanley Medical Research Institute for Funding for Non-Human Primate Research; and funded by NIMH grant R01MH074313. J.B. was supported in part by NARSAD Young Investigator Grant 27209 from the Brain & Behavior Research Foundation. G.E.H. was supported in part by NARSAD Young Investigator Grant 26313 from the Brain & Behavior Research Foundation. This work was supported in part through the computational resources and staff expertise provided by the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai. Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41597-019-0183-6",
language = "English",
volume = "6",
journal = "Scientific data",
issn = "2052-4463",
publisher = "Nature Publishing Group",
number = "1",
}