Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

Wen Zhang; Xiaogang Chen; Wei Gong; Jinsong Tang; Liwen Tan; Hao Guo; Yong Gang Yao

doi:10.1186/1744-9081-6-75

Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

Wen Zhang
, Xiaogang Chen
, Wei Gong
, Jinsong Tang
, Liwen Tan
, Hao Guo
, Yong Gang Yao

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

Original language	English
Article number	75
Journal	Behavioral and Brain Functions
Volume	6
DOIs	https://doi.org/10.1186/1744-9081-6-75
State	Published - 29 Dec 2010
Externally published	Yes

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@article{7599126b38594365995230c274f04e1d,

title = "Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese",

abstract = "Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.",

author = "Wen Zhang and Xiaogang Chen and Wei Gong and Jinsong Tang and Liwen Tan and Hao Guo and Yao, \{Yong Gang\}",

note = "Funding Information: The authors thank all subjects who participated in this study. This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301).",

year = "2010",

month = dec,

day = "29",

doi = "10.1186/1744-9081-6-75",

language = "English",

volume = "6",

journal = "Behavioral and Brain Functions",

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TY - JOUR

T1 - Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

AU - Zhang, Wen

AU - Chen, Xiaogang

AU - Gong, Wei

AU - Tang, Jinsong

AU - Tan, Liwen

AU - Guo, Hao

AU - Yao, Yong Gang

N1 - Funding Information: The authors thank all subjects who participated in this study. This work was supported by the National Natural Science Foundation of China (30925021, 30870893), Yunnan Province (2009CI119), Chinese Academy of Sciences, and National Key Basic Research and Development Program (973) (2007CB512301).

PY - 2010/12/29

Y1 - 2010/12/29

N2 - Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

AB - Background: The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.Methods: We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.Results: Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.Conclusion: The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

UR - https://www.scopus.com/pages/publications/78650605817

U2 - 10.1186/1744-9081-6-75

DO - 10.1186/1744-9081-6-75

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C2 - 21190551

AN - SCOPUS:78650605817

SN - 1744-9081

VL - 6

JO - Behavioral and Brain Functions

JF - Behavioral and Brain Functions

M1 - 75

ER -

Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese

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