Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

Kristina Dobrindt; Daisy A. Hoagland; Carina Seah; Bibi Kassim; Callan P. O'Shea; Aleta Murphy; Marina Iskhakova; Michael B. Fernando; Samuel K. Powell; P. J.Michael Deans; Ben Javidfar; Cyril Peter; Rasmus Møller; Skyler A. Uhl; Meilin Fernandez Garcia; Masaki Kimura; Kentaro Iwasawa; John F. Crary; Darrell N. Kotton; Takanori Takebe; Laura M. Huckins; Benjamin R. tenOever; Schahram Akbarian; Kristen J. Brennand

doi:10.1016/j.stemcr.2021.02.010

Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

Kristina Dobrindt, Daisy A. Hoagland, Carina Seah, Bibi Kassim, Callan P. O'Shea, Aleta Murphy, Marina Iskhakova, Michael B. Fernando, Samuel K. Powell, P. J.Michael Deans, Ben Javidfar, Cyril Peter, Rasmus Møller, Skyler A. Uhl, Meilin Fernandez Garcia, Masaki Kimura, Kentaro Iwasawa, John F. Crary, Darrell N. Kotton, Takanori TakebeLaura M. Huckins, Benjamin R. tenOever, Schahram Akbarian, Kristen J. Brennand

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37 Scopus citations

Abstract

Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro.

Original language	English
Pages (from-to)	505-518
Number of pages	14
Journal	Stem Cell Reports
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2021.02.010
State	Published - 9 Mar 2021

Keywords

FURIN rs4702
SARS-CoV-2
brain
host genetics
human induced pluripotent stem cell
neurons

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10.1016/j.stemcr.2021.02.010

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Dobrindt, K., Hoagland, D. A., Seah, C., Kassim, B., O'Shea, C. P., Murphy, A., Iskhakova, M., Fernando, M. B., Powell, S. K., Deans, P. J. M., Javidfar, B., Peter, C., Møller, R., Uhl, S. A., Garcia, M. F., Kimura, M., Iwasawa, K., Crary, J. F., Kotton, D. N., ... Brennand, K. J. (2021). Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports, 16(3), 505-518. https://doi.org/10.1016/j.stemcr.2021.02.010

@article{91b7d3c0c8794a6aad5e01146043d31a,

title = "Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection",

abstract = "Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro.",

keywords = "FURIN rs4702, SARS-CoV-2, brain, host genetics, human induced pluripotent stem cell, neurons",

author = "Kristina Dobrindt and Hoagland, \{Daisy A.\} and Carina Seah and Bibi Kassim and O'Shea, \{Callan P.\} and Aleta Murphy and Marina Iskhakova and Fernando, \{Michael B.\} and Powell, \{Samuel K.\} and Deans, \{P. J.Michael\} and Ben Javidfar and Cyril Peter and Rasmus M{\o}ller and Uhl, \{Skyler A.\} and Garcia, \{Meilin Fernandez\} and Masaki Kimura and Kentaro Iwasawa and Crary, \{John F.\} and Kotton, \{Darrell N.\} and Takanori Takebe and Huckins, \{Laura M.\} and tenOever, \{Benjamin R.\} and Schahram Akbarian and Brennand, \{Kristen J.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = mar,

day = "9",

doi = "10.1016/j.stemcr.2021.02.010",

language = "English",

volume = "16",

pages = "505--518",

journal = "Stem Cell Reports",

issn = "2213-6711",

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Dobrindt, K, Hoagland, DA, Seah, C, Kassim, B, O'Shea, CP, Murphy, A, Iskhakova, M, Fernando, MB, Powell, SK, Deans, PJM, Javidfar, B, Peter, C, Møller, R, Uhl, SA, Garcia, MF, Kimura, M, Iwasawa, K, Crary, JF, Kotton, DN, Takebe, T, Huckins, LM, tenOever, BR, Akbarian, S & Brennand, KJ 2021, 'Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection', Stem Cell Reports, vol. 16, no. 3, pp. 505-518. https://doi.org/10.1016/j.stemcr.2021.02.010

TY - JOUR

T1 - Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

AU - Dobrindt, Kristina

AU - Hoagland, Daisy A.

AU - Seah, Carina

AU - Kassim, Bibi

AU - O'Shea, Callan P.

AU - Murphy, Aleta

AU - Iskhakova, Marina

AU - Fernando, Michael B.

AU - Powell, Samuel K.

AU - Deans, P. J.Michael

AU - Javidfar, Ben

AU - Peter, Cyril

AU - Møller, Rasmus

AU - Uhl, Skyler A.

AU - Garcia, Meilin Fernandez

AU - Kimura, Masaki

AU - Iwasawa, Kentaro

AU - Crary, John F.

AU - Kotton, Darrell N.

AU - Takebe, Takanori

AU - Huckins, Laura M.

AU - tenOever, Benjamin R.

AU - Akbarian, Schahram

AU - Brennand, Kristen J.

PY - 2021/3/9

Y1 - 2021/3/9

N2 - Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro.

AB - Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro.

KW - FURIN rs4702

KW - SARS-CoV-2

KW - brain

KW - host genetics

KW - human induced pluripotent stem cell

KW - neurons

UR - https://www.scopus.com/pages/publications/85101957590

U2 - 10.1016/j.stemcr.2021.02.010

DO - 10.1016/j.stemcr.2021.02.010

M3 - Article

C2 - 33636110

AN - SCOPUS:85101957590

SN - 2213-6711

VL - 16

SP - 505

EP - 518

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

Abstract

Keywords

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