@article{91b7d3c0c8794a6aad5e01146043d31a,
title = "Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection",
abstract = "Brennand, Akbarian, and colleagues combine human induced pluripotent stem cell-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2 in alveolar cells, intestinal cells, and neurons. A SNP(rs4702) located in the 3′ UTR of the protease FURIN influences alveolar and neuron infection by SARS-CoV-2 in vitro.",
keywords = "FURIN rs4702, SARS-CoV-2, brain, host genetics, human induced pluripotent stem cell, neurons",
author = "Kristina Dobrindt and Hoagland, {Daisy A.} and Carina Seah and Bibi Kassim and O'Shea, {Callan P.} and Aleta Murphy and Marina Iskhakova and Fernando, {Michael B.} and Powell, {Samuel K.} and Deans, {P. J.Michael} and Ben Javidfar and Cyril Peter and Rasmus M{\o}ller and Uhl, {Skyler A.} and Garcia, {Meilin Fernandez} and Masaki Kimura and Kentaro Iwasawa and Crary, {John F.} and Kotton, {Darrell N.} and Takanori Takebe and Huckins, {Laura M.} and tenOever, {Benjamin R.} and Schahram Akbarian and Brennand, {Kristen J.}",
note = "Funding Information: This work was supported by R56 MH101454 (K.J.B.), R01MH106056 (K.J.B. S.A.), 1U01DA048279-01 (S.A.), the NIH Director's New Innovator Award (DP2 DK128799-01) (T.T.), and the New York Stem Cell Foundation (K.J.B and T.T.), as well as COVID-19 seed fund 0285VV12 from the Icahn School of Medicine at Mount Sinai. All hiPSC research was conducted under the oversight of the Institutional Review Board (IRB) and Embryonic Stem Cell Research Overview (ESCRO) committees at the Icahn School of Medicine at Mount Sinai (ISSMS). Informed consent was obtained from all skin cell donors as part of a study directed by Judith Rapoport MD at the National Institute of Mental Health (NIMH). Funding Information: This work was supported by R56 MH101454 (K.J.B.), R01MH106056 (K.J.B., S.A.), 1U01DA048279-01 (S.A.), the NIH Director's New Innovator Award ( DP2 DK128799-01 ) (T.T.), and the New York Stem Cell Foundation (K.J.B and T.T.), as well as COVID-19 seed fund 0285VV12 from the Icahn School of Medicine at Mount Sinai . All hiPSC research was conducted under the oversight of the Institutional Review Board (IRB) and Embryonic Stem Cell Research Overview (ESCRO) committees at the Icahn School of Medicine at Mount Sinai (ISSMS). Informed consent was obtained from all skin cell donors as part of a study directed by Judith Rapoport MD at the National Institute of Mental Health (NIMH). Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = mar,
day = "9",
doi = "10.1016/j.stemcr.2021.02.010",
language = "English",
volume = "16",
pages = "505--518",
journal = "Stem Cell Reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "3",
}