Common genetic factors for hematological traits in humans

Yukinori Okada, Yoichiro Kamatani

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Hematological traits are essential biomedical indicators that are widely used in clinical practice. The elucidation of the etiology that determines an individual's hematological traits would have a substantial impact. Hematological traits are known to be heritable, and it has been suggested that genetic factors contribute significantly to the inter-individual variance of these traits. Here, we review our current knowledge regarding the genetic architecture of hematological traits in humans, most of which has been obtained through recent developments in genome-wide association studies (GWAS). In addition to current knowledge, which is based on the hematological traits of the three major blood-cell lineages (white blood cells; WBC, red blood cells; RBC, and platelets; PLT), we propose future approaches that would be useful as a next step in the post-GWAS era.

Original languageEnglish
Pages (from-to)161-169
Number of pages9
JournalJournal of Human Genetics
Volume57
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • GWAS
  • hematological trait
  • quantitative trait

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