Combined Short- and Long-term Therapy for the Treatment of Cytomegalovirus Retinitis Using Ganciclovir (BW B759U)

Juan Orellana; Steven A. Teich; Alan H. Friedman; Frantz Lerebours; Jacqueline Winterkorn; Donna Mildvan

doi:10.1016/S0161-6420(87)33536-5

Combined Short- and Long-term Therapy for the Treatment of Cytomegalovirus Retinitis Using Ganciclovir (BW B759U)

Juan Orellana, Steven A. Teich, Alan H. Friedman, Frantz Lerebours, Jacqueline Winterkorn, Donna Mildvan

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.

Original language	English
Pages (from-to)	831-838
Number of pages	8
Journal	Ophthalmology
Volume	94
Issue number	7
DOIs	https://doi.org/10.1016/S0161-6420(87)33536-5
State	Published - 1987

Keywords

BW B759U
DHPG
acquired immune deficiency syndrome
cytomegalovirus retinitis
ganciclovir
infectious retinitis

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10.1016/S0161-6420(87)33536-5

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title = "Combined Short- and Long-term Therapy for the Treatment of Cytomegalovirus Retinitis Using Ganciclovir (BW B759U)",

abstract = "A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.",

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T1 - Combined Short- and Long-term Therapy for the Treatment of Cytomegalovirus Retinitis Using Ganciclovir (BW B759U)

AU - Orellana, Juan

AU - Teich, Steven A.

AU - Friedman, Alan H.

AU - Lerebours, Frantz

AU - Winterkorn, Jacqueline

AU - Mildvan, Donna

PY - 1987

Y1 - 1987

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AB - A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.

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KW - DHPG

KW - acquired immune deficiency syndrome

KW - cytomegalovirus retinitis

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Combined Short- and Long-term Therapy for the Treatment of Cytomegalovirus Retinitis Using Ganciclovir (BW B759U)

Abstract

Keywords

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