Combined reduced Forced Expiratory Volume in 1 Second (FEV1) and peripheral artery disease in sedentary elders with functional limitations

Carlos A. Vaz Fragoso, Fang Chi Hsu, Tina Brinkley, Timothy Church, Christine K. Liu, Todd Manini, Anne B. Newman, Randall S. Stafford, Mary M. McDermott, Thomas M. Gill

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives: Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations. Design: Cross sectional. Setting: Lifestyle Interventions and Independence in Elder (LIFE) Study. Participants: A total of 1307 sedentary community-dwelling persons, mean age 78.9, with functional limitations (Short Physical Performance Battery [SPPB] <10). Measurements: A reduced FEV1 was defined by a z-score less than-1.64 (<lower limit of normal), whereas PAD was defined by an ankle-brachial index less than 1.00. Exertional dyspnea was defined as moderate to severe (modified Borg index) immediately after a 400-meter walk test (400MWT). Exertional leg symptoms were established by the San Diego Claudication Questionnaire. Physical inactivity was evaluated by percent of accelerometry wear-time with activity less than 100 counts per minute (top quartile established high sedentary time). Mobility was evaluated by the 400MWT (gait speed <0.8 m/s defined as slow) and SPPB (≤7 defined moderate-to-severe mobility impairment). Results: A combined reduced FEV1 and PAD was established in 6.0% (78/1307) of participants. However, among those who had a reduced FEV1, 34.2% (78/228) also had PAD, whereas 20.8% (78/375) of those who had PAD also had a reduced FEV1. The 2 combined conditions were associated with exertional dyspnea (adjusted odds ratio [adjOR] 2.59 [1.20-5.60]) and slow gait speed (adjOR 3.15 [1.72-5.75]) but not with exertional leg symptoms, high sedentary time, and moderate-to-severe mobility impairment. Conclusions: In sedentary community-dwelling elders with functional limitations, a reduced FEV1 and PAD frequently coexisted and, in combination, were strongly associated with exertional dyspnea and slow gait speed (a frailty indicator that increases the risk of deleterious outcomes).

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalJournal of the American Medical Directors Association
Issue number9
StatePublished - Sep 2014
Externally publishedYes


  • FEV1
  • Mobility
  • Peripheral artery disease
  • Sedentary


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