Combined pre operative irradiation and surgery for advanced cancer of the larynx and laryngopharynx. (A 14 year correlative statistical and histopathological study)

J. L. Goldman, J. D. Roffman

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4 Scopus citations

Abstract

A carefully planned clinical program of combined preoperative radiation and surgery has been conducted by the Department of Otolaryngology at the Mount Sinai Hospital for 14 yr in an effort to improve the survival rate for advanced cancer of the larynx and laryngopharynx. An extensive histopathological study of resected larynges and radical neck specimens was undertaken in 1961 in order to determine the effects of pre operative radiation. A very careful statistical analysis has been made of the survival experience of this series of cases. The three and five year survival rates have been computed by the actuarial method. The histopathological study entailed a serial section of 26 larynges and 21 radical neck dissection specimens. These studies have been most informative as to the nature of the radiobiologic process involved in the destruction of laryngeal cancer. In addition, the study has been revealing as to the ability of radiation to sterilize cancer in the neck specimens. The clinical correlate of this histologic finding has been the observation of reduced cervical recurrences in patients treated with combined therapy. In conclusion, statistics seem to indicate that combined therapy method has improved the survival rates of patients with advanced cancer of the larynx and laryngopharynx.

Original languageEnglish
Pages (from-to)251-264
Number of pages14
JournalJournal of Otolaryngology - Head and Neck Surgery
Volume4
Issue number2
StatePublished - 1975
Externally publishedYes

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