TY - JOUR
T1 - Combined exfoliation and pigment dispersion
T2 - Paradigm of an overlap syndrome
AU - Ritch, Robert
AU - Mudumbai, Raghu
AU - Liebmann, Jeffrey M.
N1 - Funding Information:
Supported in part by the Irving and Rena Katz Research Fund of the New York Glaucoma Research Institute, New York, New York.
PY - 2000
Y1 - 2000
N2 - Objective: To describe a series of patients with combined pigment dispersion syndrome (PDS) and exfoliation syndrome (XFS) and to introduce a concept, the overlap syndrome, to aid in assessing multiple risk factors for glaucomatous damage. Design: Clinic-based, cross-sectional study. Setting: New York Eye and Ear Infirmary. Participants: Twenty-six patients identified from the glaucoma database as having combined pigment dispersion syndrome-glaucoma and exfoliation syndrome-glaucoma. Main Outcome Measures: Quantification of patients with both pigment dispersion syndrome-glaucoma (PDS/PG) and exfoliation syndrome-glaucoma (XFS/XFG) and its clinical implications. Results: Among the 26 patients (all white) having both XFS/XFG and PDS/PG, the average age was 64.3 ± 9.8 years and 19 of 26 were men. All patients had bilateral PDS/PG. Bilateral XFS/XFG was present in 9 of 26 patients and, of the 17 patients with unilateral involvement, the left eye was affected in 13. Conclusions: Both XFS and PDS are common. Middle-aged patients with known PDS/PG should be suspected of having the onset of XFS if one eye escapes intraocular pressure control. Patients with unilateral XFG at presentation may also have signs of PDS/PG, often remitted. We define the term overlap syndrome to describe the sequential appearance over time of two or more risk factors for glaucomatous damage. The appearance of a new risk factor in a patient whose condition has been stable can alter the course and prognosis of the disease. This concept should prove useful in dealing with secondary and normal-tension glaucomas. (C) 2000 by the American Academy of Ophthalmology.
AB - Objective: To describe a series of patients with combined pigment dispersion syndrome (PDS) and exfoliation syndrome (XFS) and to introduce a concept, the overlap syndrome, to aid in assessing multiple risk factors for glaucomatous damage. Design: Clinic-based, cross-sectional study. Setting: New York Eye and Ear Infirmary. Participants: Twenty-six patients identified from the glaucoma database as having combined pigment dispersion syndrome-glaucoma and exfoliation syndrome-glaucoma. Main Outcome Measures: Quantification of patients with both pigment dispersion syndrome-glaucoma (PDS/PG) and exfoliation syndrome-glaucoma (XFS/XFG) and its clinical implications. Results: Among the 26 patients (all white) having both XFS/XFG and PDS/PG, the average age was 64.3 ± 9.8 years and 19 of 26 were men. All patients had bilateral PDS/PG. Bilateral XFS/XFG was present in 9 of 26 patients and, of the 17 patients with unilateral involvement, the left eye was affected in 13. Conclusions: Both XFS and PDS are common. Middle-aged patients with known PDS/PG should be suspected of having the onset of XFS if one eye escapes intraocular pressure control. Patients with unilateral XFG at presentation may also have signs of PDS/PG, often remitted. We define the term overlap syndrome to describe the sequential appearance over time of two or more risk factors for glaucomatous damage. The appearance of a new risk factor in a patient whose condition has been stable can alter the course and prognosis of the disease. This concept should prove useful in dealing with secondary and normal-tension glaucomas. (C) 2000 by the American Academy of Ophthalmology.
UR - http://www.scopus.com/inward/record.url?scp=0033805401&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(00)00058-0
DO - 10.1016/S0161-6420(00)00058-0
M3 - Article
C2 - 10811097
AN - SCOPUS:0033805401
SN - 0161-6420
VL - 107
SP - 1004
EP - 1008
JO - Ophthalmology
JF - Ophthalmology
IS - 5
ER -