Combined analysis of three genome-wide association studies on VWF and FVIII plasma levels

Guillemette Antoni, Tiphaine Oudot-Mellakh, Apostolos Dimitromanolakis, Marine Germain, William Cohen, Philip Wells, Mark Lathrop, France Gagnon, Pierre Emmanuel Morange, David Alexandre Tregouet

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Elevated plasma levels of factor VIII (FVIII) and von Willebrand factor (vWF), two key molecules of the coagulation cascade, are well-established risk factors for venous thrombosis (VT) [1-3]. More recent evidence shows that these plasma hemostatic proteins are also risk factors for other cardiovascular diseases (CVD) [4-8]. The broader role of FVIII and vWF is further supported by studies showing that genetic factors modulating the variability of these proteins are also associated with CVD. These include single nucleotide polymorphisms (SNPs) at the BAI3 [9], LDLR [5, 10], VWF [4] and ABO [11] genes, the latter being associated with other quantitative risk factors for CVD [12, 13].

Original languageEnglish
Title of host publicationBioinformatics
Subtitle of host publicationThe Impact of Accurate Quantification on Proteomic and Genetic Analysis and Research
PublisherApple Academic Press
Pages265-292
Number of pages28
ISBN (Electronic)9781482246629
ISBN (Print)9781771880190
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

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