Combination therapy in the management of LUTS - Is this the future?

Bilal Chughtai, Richard Lee, Alexis E. Te, Steven Kaplan

Research output: Contribution to journalReview articlepeer-review


The treatment of LUTS (Lower Urinary Tract Symptoms) has evolved from primarily surgical to medical management. Medical management itself has evolved from single agent to combination therapy. Treatments for BPH (Benign Prostatic Hyperplasia) are aimed at improving subjective symptoms and quality of life. a- Blockers and 5-a reductase inhibitors are the two main categories for treatment. In addition, both antimuscarinic agents and phosphodiesterase inhibitors have been shown to be effective in the management of LUTS. We discuss the current role of these agents in combination for the management of LUTS associated with BPH.

Original languageEnglish
Pages (from-to)e15-e19
JournalDrug Discovery Today: Therapeutic Strategies
Issue number1
StatePublished - 2012
Externally publishedYes


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