Combination therapy

Even in mild cases of psoriasis, therapy with a single topical agent often fails to provide patients with adequate disease control. Fortunately, valid alternatives are available, as topical agents can be used in conjunction with other topical medications, systemic therapies, and phototherapy through a combinational, sequential, or rotational approach to treatment. This translates into management plans that extend from the simultaneous use of two treatment entities to well-choreographed time courses featuring multiple therapeutic agents. Situations in the treatment of mildto- moderate psoriasis that may warrant this approach include refractory disease, acute flares, poor quality of life, or an upcoming major life event for which total clearance is desired. Diversifying treatment tends to reduce the required dosages and adverse effects associated with aggressive treatment modalities, as well as benefit the patient through potential cost reduction, ease of administration, and improved quality of life.