Combination, Rotational, and Sequential Therapy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations


The concept of rotational therapy was first introduced by Weinstein and White (1). At that time ultraviolet B (UVB) plus tar, psoralen plus UVA (PUVA), methotrexate, and etretinate were the treatments available for severe psoriasis. Weinstein and White advocated using each form of therapy for 1-2 years and then switching to the next form. By rotating these treatments, the cumulative toxicity of each individual form of therapy could be minimized, thus reducing the carcinogenesis of PUVA, the hepatic fibrosis and need for liver biopsies with methotrexate, and the musculoskeletal toxicity of retinoids. As new treatments, such as cyclosporine, were developed, they were added to the rotation, allowing further reductions in cumulative dosage over time.

Original languageEnglish
Title of host publicationTherapy of Moderate-to-Severe Psoriasis, Second Edition, Revised and Expanded
PublisherCRC Press
Number of pages18
ISBN (Electronic)9780824748173
ISBN (Print)9781420088687
StatePublished - 1 Jan 2003


Dive into the research topics of 'Combination, Rotational, and Sequential Therapy'. Together they form a unique fingerprint.

Cite this