TY - JOUR
T1 - Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B
AU - Malik, R.
AU - Craig, A. J.
AU - Wigney, I.
AU - Martin, P.
AU - Love, D. N.
PY - 1996/4
Y1 - 1996/4
N2 - Six cases (3 cats, 3 dogs) of cryptococcosis were cured using combination chemotherapy that included amphotericin B. We developed a simple, practical and inexpensive method of administering amphotericin B as a subcutaneous infusion during the treatment of these patients. For this, the calculated dose of amphotericin B (0.5 to 0.8 mg/kg) was added to 400 mL, for cats, or to 500 mL, for dogs, of 0.45% saline containing 2.5% dextrose. These amounts were given subcutaneously 2 or 3 times weekly over several months, to a total cumulative dose of 8 to 26 mg/kg body weight. Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia.
AB - Six cases (3 cats, 3 dogs) of cryptococcosis were cured using combination chemotherapy that included amphotericin B. We developed a simple, practical and inexpensive method of administering amphotericin B as a subcutaneous infusion during the treatment of these patients. For this, the calculated dose of amphotericin B (0.5 to 0.8 mg/kg) was added to 400 mL, for cats, or to 500 mL, for dogs, of 0.45% saline containing 2.5% dextrose. These amounts were given subcutaneously 2 or 3 times weekly over several months, to a total cumulative dose of 8 to 26 mg/kg body weight. Subcutaneous infusions were generally well tolerated by the animals, although concentrations of amphotericin B in excess of 20 mg/L resulted in local irritation. This protocol enabled the administration of larger, and thus more effective, quantities of amphotericin B without producing marked azotaemia.
UR - http://www.scopus.com/inward/record.url?scp=0030119909&partnerID=8YFLogxK
U2 - 10.1111/j.1751-0813.1996.tb10003.x
DO - 10.1111/j.1751-0813.1996.tb10003.x
M3 - Article
C2 - 8660225
AN - SCOPUS:0030119909
SN - 0005-0423
VL - 73
SP - 124
EP - 128
JO - Australian Veterinary Journal
JF - Australian Veterinary Journal
IS - 4
ER -