TY - JOUR
T1 - Colonic infiltration with chronic myelomonocytic leukemia
AU - LoSavio, Andelka D.
AU - Bunnag, Alana P.
AU - Rubin, David T.
PY - 2007/4
Y1 - 2007/4
N2 - Background: A 75-year-old female presented with a 1 month history of nonbloody diarrhea, associated with abdominal cramping and urgency. Her medical history was notable for chronic myelomonocytic leukemia, diagnosed 6 years previously and managed expectantly by monitoring the patient's complete blood count. Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death. Investigations: Physical examination, laboratory investigations, stool studies, colonoscopy with biopsies, immunohistochemistry and pathologic review of biopsy specimens. Diagnosis: Leukemic colitis. Management: Management of underlying leukemia with systemic hydroxyurea and topical colonic 5-aminosalicylic acid therapy.
AB - Background: A 75-year-old female presented with a 1 month history of nonbloody diarrhea, associated with abdominal cramping and urgency. Her medical history was notable for chronic myelomonocytic leukemia, diagnosed 6 years previously and managed expectantly by monitoring the patient's complete blood count. Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death. Investigations: Physical examination, laboratory investigations, stool studies, colonoscopy with biopsies, immunohistochemistry and pathologic review of biopsy specimens. Diagnosis: Leukemic colitis. Management: Management of underlying leukemia with systemic hydroxyurea and topical colonic 5-aminosalicylic acid therapy.
UR - https://www.scopus.com/pages/publications/34247186962
U2 - 10.1038/ncpgasthep0771
DO - 10.1038/ncpgasthep0771
M3 - Article
C2 - 17404590
AN - SCOPUS:34247186962
SN - 1743-4378
VL - 4
SP - 229
EP - 233
JO - Nature Clinical Practice Gastroenterology and Hepatology
JF - Nature Clinical Practice Gastroenterology and Hepatology
IS - 4
ER -