TY - JOUR
T1 - Collagens in cancer
T2 - structural regulators and guardians of cancer progression
AU - De Martino, Daniela
AU - Bravo-Cordero, Jose Javier
N1 - Funding Information:
Gregory for her illustrations. This work was supported by an NCI R01 (CA244780) and the Tisch Cancer
Funding Information:
Institute NIH Cancer Center grant (P30 CA196521).
Funding Information:
We want to thank Erin Bresnahan and Swagata Basu for critical reading and editing of the manuscript and Jill Gregory for her illustrations. This work was supported by an NCI R01 (CA244780) and the Tisch Cancer Institute NIH Cancer Center grant (P30 CA196521).
Publisher Copyright:
© 2023 American Association for Cancer Research Inc.. All rights reserved.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Collagen is one of the most abundant proteins in animals and a major component of the extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of tissues, collagens can modulate the behavior of cells, and their deregulation can promote diseases such as cancer. In tumors, collagens and many other ECM molecules are mainly produced by fibroblasts, and recent evidence points towards a role of tumor-derived collagens in tumor progression and metastasis. In this review, we focus on the newly discovered functions of collagens in cancer. Novel findings have revealed the role of collagens in tumor dormancy and immune evasion, as well as their interplay with cancer cell metabolism. Collagens could serve as prognostic markers for cancer patients, and therapeutic strategies targeting the collagen ECM have the potential to prevent tumor progression and metastasis.
AB - Collagen is one of the most abundant proteins in animals and a major component of the extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of tissues, collagens can modulate the behavior of cells, and their deregulation can promote diseases such as cancer. In tumors, collagens and many other ECM molecules are mainly produced by fibroblasts, and recent evidence points towards a role of tumor-derived collagens in tumor progression and metastasis. In this review, we focus on the newly discovered functions of collagens in cancer. Novel findings have revealed the role of collagens in tumor dormancy and immune evasion, as well as their interplay with cancer cell metabolism. Collagens could serve as prognostic markers for cancer patients, and therapeutic strategies targeting the collagen ECM have the potential to prevent tumor progression and metastasis.
UR - http://www.scopus.com/inward/record.url?scp=85159246291&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-22-2034
DO - 10.1158/0008-5472.CAN-22-2034
M3 - Article
C2 - 36638361
AN - SCOPUS:85159246291
SN - 0008-5472
VL - 83
JO - Cancer Research
JF - Cancer Research
IS - 9
ER -