Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation

Noritaka Matsuo, Shizuko Tanaka, Hidekatsu Yoshioka, Manuel Koch, Marion K. Gordon, Francesco Ramirez

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Collagen XXIV is an ill-characterized fibrillar collagen that is predominantly expressed in the forming skeleton of the mouse embryo. Here we report that the Col24al gene is constitutively transcribed in the trabecular bone and periosteum of the newborn mouse as well. The bone specificity of Col24al was further documented using three well-characterized cell culture models of osteoblast differentiation. These in vitro analyses indicated that Col24al transcription is activated at about the same time as that of the osteocalcin gene, and gradually increases to eventually plateau as osteoblasts begin to deposit a mineralizing matrix. These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalConnective Tissue Research
Volume49
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • Bone
  • Extracellular matrix
  • Fibrillar collagens
  • Mineralization
  • Osteoblasts

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