TY - JOUR
T1 - COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)
AU - Smith, Douglas H.
AU - Dollé, Jean Pierre
AU - Ameen-Ali, Kamar E.
AU - Bretzin, Abigail
AU - Cortes, Etty
AU - Crary, John F.
AU - Dams-O’Connor, Kristen
AU - Diaz-Arrastia, Ramon
AU - Edlow, Brian L.
AU - Folkerth, Rebecca
AU - Hazrati, Lili Naz
AU - Hinds, Sidney R.
AU - Iacono, Diego
AU - Johnson, Victoria E.
AU - Keene, C. Dirk
AU - Kofler, Julia
AU - Kovacs, Gabor G.
AU - Lee, Edward B.
AU - Manley, Geoffrey
AU - Meaney, David
AU - Montine, Thomas
AU - Okonkwo, David O.
AU - Perl, Daniel P.
AU - Trojanowski, John Q.
AU - Wiebe, Douglas J.
AU - Yaffe, Kristine
AU - McCabe, Thomas
AU - Stewart, William
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic encephalopathy (CTE) in former contact sports athletes and others exposed to repetitive head impacts. However, the association between TBI and dementia risk has long been acknowledged outside of contact sports. Further, growing experience suggests a complex of neurodegenerative pathologies in those surviving TBI, which extends beyond CTE. Nevertheless, despite extensive research, we have scant knowledge of the mechanisms underlying TBI-related neurodegeneration (TReND) and its link to dementia. In part, this is due to the limited number of human brain samples linked to robust demographic and clinical information available for research. Here we detail a National Institutes for Neurological Disease and Stroke Center Without Walls project, the COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI), designed to address current limitations in tissue and research access and to advance understanding of the neuropathologies of TReND. As an international, multidisciplinary collaboration CONNECT-TBI brings together multiple experts across 13 institutions. In so doing, CONNECT-TBI unites the existing, comprehensive clinical and neuropathological datasets of multiple established research brain archives in TBI, with survivals ranging minutes to many decades and spanning diverse injury exposures. These existing tissue specimens will be supplemented by prospective brain banking and contribute to a centralized route of access to human tissue for research for investigators. Importantly, each new case will be subject to consensus neuropathology review by the CONNECT-TBI Expert Pathology Group. Herein we set out the CONNECT-TBI program structure and aims and, by way of an illustrative case, the approach to consensus evaluation of new case donations.
AB - Efforts to characterize the late effects of traumatic brain injury (TBI) have been in progress for some time. In recent years much of this activity has been directed towards reporting of chronic traumatic encephalopathy (CTE) in former contact sports athletes and others exposed to repetitive head impacts. However, the association between TBI and dementia risk has long been acknowledged outside of contact sports. Further, growing experience suggests a complex of neurodegenerative pathologies in those surviving TBI, which extends beyond CTE. Nevertheless, despite extensive research, we have scant knowledge of the mechanisms underlying TBI-related neurodegeneration (TReND) and its link to dementia. In part, this is due to the limited number of human brain samples linked to robust demographic and clinical information available for research. Here we detail a National Institutes for Neurological Disease and Stroke Center Without Walls project, the COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI), designed to address current limitations in tissue and research access and to advance understanding of the neuropathologies of TReND. As an international, multidisciplinary collaboration CONNECT-TBI brings together multiple experts across 13 institutions. In so doing, CONNECT-TBI unites the existing, comprehensive clinical and neuropathological datasets of multiple established research brain archives in TBI, with survivals ranging minutes to many decades and spanning diverse injury exposures. These existing tissue specimens will be supplemented by prospective brain banking and contribute to a centralized route of access to human tissue for research for investigators. Importantly, each new case will be subject to consensus neuropathology review by the CONNECT-TBI Expert Pathology Group. Herein we set out the CONNECT-TBI program structure and aims and, by way of an illustrative case, the approach to consensus evaluation of new case donations.
KW - Chronic traumatic encephalopathy
KW - Concussion
KW - Dementia
KW - Neurodegenerative disease
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85101877789&partnerID=8YFLogxK
U2 - 10.1186/s40478-021-01122-9
DO - 10.1186/s40478-021-01122-9
M3 - Article
C2 - 33648593
AN - SCOPUS:85101877789
SN - 2051-5960
VL - 9
JO - Acta neuropathologica communications
JF - Acta neuropathologica communications
IS - 1
M1 - 32
ER -