TY - JOUR
T1 - Cohort profile
T2 - Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study
AU - Bi, Yufang
AU - Lu, Jieli
AU - Wang, Weiqing
AU - Mu, Yiming
AU - Zhao, Jiajun
AU - Liu, Chao
AU - Chen, Lulu
AU - Shi, Lixin
AU - Li, Qiang
AU - Wan, Qin
AU - Wu, Shengli
AU - Yang, Tao
AU - Yan, Li
AU - Liu, Yan
AU - Wang, Guixia
AU - Luo, Zuojie
AU - Tang, Xulei
AU - Chen, Gang
AU - Huo, Yanan
AU - Gao, Zhengnan
AU - Su, Qing
AU - Ye, Zhen
AU - Wang, Youming
AU - Qin, Guijun
AU - Deng, Huacong
AU - Yu, Xuefeng
AU - Shen, Feixia
AU - Chen, Li
AU - Zhao, Liebin
AU - Zhang, Jie
AU - Sun, Jichao
AU - Dai, Meng
AU - Xu, Min
AU - Xu, Yu
AU - Chen, Yuhong
AU - Lai, Shenghan
AU - Bloomgarden, Zachary T.
AU - Li, Donghui
AU - Ning, Guang
PY - 2014/3
Y1 - 2014/3
N2 - Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.
AB - Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.
KW - Cancer
KW - Diabetes
KW - REACTION study
UR - http://www.scopus.com/inward/record.url?scp=84895070193&partnerID=8YFLogxK
U2 - 10.1111/1753-0407.12108
DO - 10.1111/1753-0407.12108
M3 - Article
C2 - 24237858
AN - SCOPUS:84895070193
SN - 1753-0393
VL - 6
SP - 147
EP - 157
JO - Journal of Diabetes
JF - Journal of Diabetes
IS - 2
ER -