Cognitive strategies shift information from single neurons to populations in prefrontal cortex

Feng Kuei Chiang, Joni D. Wallis, Erin L. Rich

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Neurons in primate lateral prefrontal cortex (LPFC) play a critical role in working memory (WM) and cognitive strategies. Consistent with adaptive coding models, responses of these neurons are not fixed but flexibly adjust on the basis of cognitive demands. However, little is known about how these adjustments affect population codes. Here, we investigated ensemble coding in LPFC while monkeys implemented different strategies in a WM task. Although single neurons were less tuned when monkeys used more stereotyped strategies, task information could still be accurately decoded from neural populations. This was due to changes in population codes that distributed information among a greater number of neurons, each contributing less to the overall population. Moreover, this shift occurred for task-relevant, but not irrelevant, information. These results demonstrate that cognitive strategies that impose structure on information held in mind rearrange population codes in LPFC, such that information becomes more distributed among neurons in an ensemble.

Original languageEnglish
Pages (from-to)709-721.e4
JournalNeuron
Volume110
Issue number4
DOIs
StatePublished - 16 Feb 2022

Keywords

  • cognitive strategy
  • decoding
  • dimensionality
  • lateral prefrontal cortex
  • macaque monkey
  • neural ensemble
  • population coding
  • spatial tuning
  • working memory

Fingerprint

Dive into the research topics of 'Cognitive strategies shift information from single neurons to populations in prefrontal cortex'. Together they form a unique fingerprint.

Cite this