TY - JOUR
T1 - Cognitive and symptomatic predictors of functional disability in schizophrenia
AU - Shamsi, Syed
AU - Lau, Adam
AU - Lencz, Todd
AU - Burdick, Katherine E.
AU - DeRosse, Pamela
AU - Brenner, Ron
AU - Lindenmayer, Jean Pierre
AU - Malhotra, Anil K.
N1 - Funding Information:
Funding for this study was provided by NIMH through grants R01MH079800 and P50MH080173. The study sponsor had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2011/3
Y1 - 2011/3
N2 - Background: Neurocognition and negative symptoms play a major role in predicting functional outcomes in patients with schizophrenia. Few studies have assessed the relationship between functional outcomes and the MATRICS consensus cognition battery (MCCB), which will be central to future clinical trials of cognitive enhancing agents. Aims: To assess the role of individual MCCB domains on functional outcomes. Method: 185 stable outpatients with schizophrenia were enrolled and assessed with the MCCB, Social Adjustment Scale-II (SAS-II) and Multidimensional Scale for Independent Functioning (MSIF), along with BPRS and SANS. Results: We found significant relationships between MCCB neurocognitive domain scores, negative symptoms and aspects of functional outcome in schizophrenia. Specifically, we found that work/education functioning is predicted by working memory performance and negative symptoms; residential status (independent living) is predicted by verbal memory scores; and social functioning is predicted by social cognition, attention and negative symptoms. We also found that negative symptom severity was not related to residential status, even though it demonstrated the predicted associations to work and social functioning. Conclusion: To our knowledge, this is the first study to assess cognition and functional outcomes using MCCB, SAS II and MSIF. Our results extend prior work and help provide more data on the relationships between cognition, symptoms and functional outcome using "real world" measures.
AB - Background: Neurocognition and negative symptoms play a major role in predicting functional outcomes in patients with schizophrenia. Few studies have assessed the relationship between functional outcomes and the MATRICS consensus cognition battery (MCCB), which will be central to future clinical trials of cognitive enhancing agents. Aims: To assess the role of individual MCCB domains on functional outcomes. Method: 185 stable outpatients with schizophrenia were enrolled and assessed with the MCCB, Social Adjustment Scale-II (SAS-II) and Multidimensional Scale for Independent Functioning (MSIF), along with BPRS and SANS. Results: We found significant relationships between MCCB neurocognitive domain scores, negative symptoms and aspects of functional outcome in schizophrenia. Specifically, we found that work/education functioning is predicted by working memory performance and negative symptoms; residential status (independent living) is predicted by verbal memory scores; and social functioning is predicted by social cognition, attention and negative symptoms. We also found that negative symptom severity was not related to residential status, even though it demonstrated the predicted associations to work and social functioning. Conclusion: To our knowledge, this is the first study to assess cognition and functional outcomes using MCCB, SAS II and MSIF. Our results extend prior work and help provide more data on the relationships between cognition, symptoms and functional outcome using "real world" measures.
UR - http://www.scopus.com/inward/record.url?scp=79952007229&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2010.08.007
DO - 10.1016/j.schres.2010.08.007
M3 - Article
C2 - 20828991
AN - SCOPUS:79952007229
SN - 0920-9964
VL - 126
SP - 257
EP - 264
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -