TY - JOUR
T1 - Cognitive and personality analysis of startle reactivity in a large cohort of healthy males
AU - Giakoumaki, Stella G.
AU - Roussos, Panos
AU - Tsapakis, Eva Maria
AU - Koiliari, Erasmia
AU - Pasparakis, Emmanouil
AU - Zouraraki, Chrysoula
AU - Bitsios, Panos
N1 - Funding Information:
This project was supported by the University of Crete Research Funds Account ( E.L.K.E. 1348 ). The University of Crete Research Funds Account has not been involved in the study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
PY - 2013/12
Y1 - 2013/12
N2 - Subjects with low/undetectable startle are usually excluded from startle studies but few reports not confounded by this factor, show reduced startle in healthy impulsive subjects, or clinical populations with disorders of affect and impulsivity but also in schizophrenia and its prodrome. We examined the relationship of startle reactivity including startle "non-responding" status to cognitive and affective personality traits in a large and ethnically/demographically homogeneous cohort of healthy males from the LOGOS study, Heraklion, Crete. Startle reactivity was monotonically related to sensitivity to reward (higher in "non-responders", lower in strong responders). In addition, "non-responders" had poorer strategy, working memory and sustained attention performance compared to responder tertile groups. More research in clinical and high risk populations is required to examine if low/undetectable startle reactivity is a valuable intermediate phenotype for disorders of affect and impulsivity. It is possible that the "non-responsive" status may capture disease related features such as executive dysfunction.
AB - Subjects with low/undetectable startle are usually excluded from startle studies but few reports not confounded by this factor, show reduced startle in healthy impulsive subjects, or clinical populations with disorders of affect and impulsivity but also in schizophrenia and its prodrome. We examined the relationship of startle reactivity including startle "non-responding" status to cognitive and affective personality traits in a large and ethnically/demographically homogeneous cohort of healthy males from the LOGOS study, Heraklion, Crete. Startle reactivity was monotonically related to sensitivity to reward (higher in "non-responders", lower in strong responders). In addition, "non-responders" had poorer strategy, working memory and sustained attention performance compared to responder tertile groups. More research in clinical and high risk populations is required to examine if low/undetectable startle reactivity is a valuable intermediate phenotype for disorders of affect and impulsivity. It is possible that the "non-responsive" status may capture disease related features such as executive dysfunction.
KW - Acoustic startle reflex
KW - Executive function
KW - Impulsivity
KW - Intermediate phenotype
KW - LOGOS cohort
KW - Startle non responders
UR - http://www.scopus.com/inward/record.url?scp=84888197307&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2013.09.005
DO - 10.1016/j.biopsycho.2013.09.005
M3 - Article
C2 - 24051230
AN - SCOPUS:84888197307
SN - 0301-0511
VL - 94
SP - 582
EP - 591
JO - Biological Psychology
JF - Biological Psychology
IS - 3
ER -