Cognition in multiple sclerosis: A review of neuropsychological and fMRI research

Helen M. Genova, James F. Sumowski, Nancy Chiaravalloti, Gerald T. Voelbel, John Deluca

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Multiple Sclerosis (MS) is a disease of the central nervous system affecting millions of people worldwide. In addition to the disabling physical symptoms of MS, roughly 65% of individuals with MS also experience significant cognitive dysfunction, especially in the domains of learning/memory, processing speed (PS) and working memory (WM). The purpose of this review is to examine major topics in research on cognitive dysfunction, as well as review recent functional magnetic resonance imaging (fMRI) studies focusing on cognitive dysfunction in MS. Additionally, directions for future research are discussed.

Original languageEnglish
Pages (from-to)1730-1744
Number of pages15
JournalFrontiers in Bioscience - Landmark
Issue number5
StatePublished - 1 Jan 2009
Externally publishedYes


  • Attention
  • Cognitive dysfunction
  • Cognitive fatigue
  • Episodic memory
  • Executive function
  • Functional magnetic resonance imaging
  • Learning and memory
  • Multiple sclerosis
  • Processing speed
  • Review
  • Visual perception
  • Working memory
  • fMRI


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