Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Yvonne Leung; Nir Barzilai; Agnieszka Batko-Szwaczka; Nina Beker; Kathrin Boerner; Carol Brayne; Henry Brodaty; Karen Siu Lan Cheung; María M. Corrada; John D. Crawford; Alessia A. Galbussera; Yasuyuki Gondo; Henne Holstege; Marc Hulsman; Yoshiko Lily Ishioka; Daniela Jopp; Claudia H. Kawas; Jeff Kaye; Nicole A. Kochan; Bobo Hi Po Lau; Darren M. Lipnicki; Jessica W. Lo; Ugo Lucca; Steve R. Makkar; Gabriella Marcon; Peter Martin; Kenichi Meguro; Sofiya Milman; Leonard W. Poon; Angela Recchia; Oscar Ribeiro; Emma Riva; Christoph Rott; Sietske A.M. Sikkes; Ingmar Skoog; Blossom Stephan; Jan Szewieczek; Laetitia Teixeira; Mauro Tettamanti; Krzysztof Wilczyński; Perminder Sachdev

doi:10.1002/alz.12828

Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Yvonne Leung, Nir Barzilai, Agnieszka Batko-Szwaczka, Nina Beker, Kathrin Boerner, Carol Brayne, Henry Brodaty, Karen Siu Lan Cheung, María M. Corrada, John D. Crawford, Alessia A. Galbussera, Yasuyuki Gondo, Henne Holstege, Marc Hulsman, Yoshiko Lily Ishioka, Daniela Jopp, Claudia H. Kawas, Jeff Kaye, Nicole A. Kochan, Bobo Hi Po LauDarren M. Lipnicki, Jessica W. Lo, Ugo Lucca, Steve R. Makkar, Gabriella Marcon, Peter Martin, Kenichi Meguro, Sofiya Milman, Leonard W. Poon, Angela Recchia, Oscar Ribeiro, Emma Riva, Christoph Rott, Sietske A.M. Sikkes, Ingmar Skoog, Blossom Stephan, Jan Szewieczek, Laetitia Teixeira, Mauro Tettamanti, Krzysztof Wilczyński, Perminder Sachdev

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Original language	English
Journal	Alzheimer's and Dementia
DOIs	https://doi.org/10.1002/alz.12828
State	Accepted/In press - 2022
Externally published	Yes

Keywords

centenarians
dementia
education
exceptional longevity
prevalence
risk factors

Access to Document

10.1002/alz.12828

Cite this

Leung, Y., Barzilai, N., Batko-Szwaczka, A., Beker, N., Boerner, K., Brayne, C., Brodaty, H., Cheung, K. S. L., Corrada, M. M., Crawford, J. D., Galbussera, A. A., Gondo, Y., Holstege, H., Hulsman, M., Ishioka, Y. L., Jopp, D., Kawas, C. H., Kaye, J., Kochan, N. A., ... Sachdev, P. (Accepted/In press). Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies. Alzheimer's and Dementia. https://doi.org/10.1002/alz.12828

@article{9129d7af98074d2aa0f208c909989ece,

title = "Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies",

abstract = "Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.",

keywords = "centenarians, dementia, education, exceptional longevity, prevalence, risk factors",

author = "Yvonne Leung and Nir Barzilai and Agnieszka Batko-Szwaczka and Nina Beker and Kathrin Boerner and Carol Brayne and Henry Brodaty and Cheung, {Karen Siu Lan} and Corrada, {Mar{\'i}a M.} and Crawford, {John D.} and Galbussera, {Alessia A.} and Yasuyuki Gondo and Henne Holstege and Marc Hulsman and Ishioka, {Yoshiko Lily} and Daniela Jopp and Kawas, {Claudia H.} and Jeff Kaye and Kochan, {Nicole A.} and Lau, {Bobo Hi Po} and Lipnicki, {Darren M.} and Lo, {Jessica W.} and Ugo Lucca and Makkar, {Steve R.} and Gabriella Marcon and Peter Martin and Kenichi Meguro and Sofiya Milman and Poon, {Leonard W.} and Angela Recchia and Oscar Ribeiro and Emma Riva and Christoph Rott and Sikkes, {Sietske A.M.} and Ingmar Skoog and Blossom Stephan and Jan Szewieczek and Laetitia Teixeira and Mauro Tettamanti and Krzysztof Wilczy{\'n}ski and Perminder Sachdev",

note = "Funding Information: The authors acknowledge the contribution of the late Professor Bo Hagberg from Lund University, who was a founding member of the international centenarian consortium and had offered invaluable data from the Swedish Centenarian Study for this paper. In addition, we wish to acknowledge the contribution of Dr Thomas Marlow from the University of Gothenburg, who was involved in data sharing and review of earlier drafts of this manuscript. We also thank Ms Catriona Daly, who is a former coordinator of the ICC‐Dementia, for her contribution to the early work on the consortium and this project. The funding was supported by NHMRC Australia program grant 1093083. Individual cohorts funded by local funding bodies. Funding Information: Governmental/charity support to individual researchers and/or the contributing studies: Nir Brazilai – Grants from the National Institutes of Health (P01AG021654), The Nathan Shock Center of Excellence for the basic Biology of Aging (P30AG038072). Batko‐Szwaczka Agnieszka, Jan Szewieczek & Krzysztof Wilczy{\'n}ski – The Polish Centenarian Study (PCS) was funded by the Medical University of Silesia, Katowice, Poland (grants NN‐2‐268/06, KNW‐2‐045/08, KNW‐2‐022/09) and by the National Science Centre, Poland (grant N 404535439) from the budget for science in years 2010‐2014. Henry Brodaty & Perminder Sachdev – supported by National Health & Medical Research Council of Australia. Karen Siu‐Lan Cheung & Bobo Hi‐Po Lau – The Hong Kong data were made available from the Hong Kong Centenarian Study (HKCS) that was supported by the Seed Funding Program for Basic Research, the matching fund from the Department of Social Work and Social Administration at University of Hong Kong (Project No. 104001032), and AXA funded red packets to the participants upon the completion of the interview. Mar{\'i}a M. Corrada – NIH grant R01AG021055 (to UCI). John Dudley Crawford & Darren Lipnicki‐ salary supported by NIH Grant No. 1RF1AG057531‐01. Jeffrey Kaye – supported by National Institutes of Health (NIA) P30AG066518 & Department of Veterans Affairs. Jessica W Lo – Salary supported by Vincent Fairfax Family Foundation. Peter Martin – supported by grant: NIH (1 PO1 AG17553‐01A1) & National Institute of Food and Agriculture (Hatch Project Grant, IOW04116). Sofiya Milman – supported by NIH, AFAR, and Glenn Foundation for Biomedical Research. Oscar Ribeiro & Laetitia Teixeira – The PT100 – Oporto Centenarian Study was supported by the Portuguese Foundation for Science and Technology (FCT; Grant Pest‐C/SAU/UI0688/2011 and C/SAU/UI0688/2014). Sietske Sikkes – supported by ZonMW, #7330502051, ZonMW, #73305095008, Health∼Holland, Topsector Life Sciences & Health (PPP‐allowance; #LSHM20084), Health∼Holland, Topsector Life Sciences & Health (#LSHM19051). Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2022",

doi = "10.1002/alz.12828",

language = "English",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

}

Leung, Y, Barzilai, N, Batko-Szwaczka, A, Beker, N, Boerner, K, Brayne, C, Brodaty, H, Cheung, KSL, Corrada, MM, Crawford, JD, Galbussera, AA, Gondo, Y, Holstege, H, Hulsman, M, Ishioka, YL, Jopp, D, Kawas, CH, Kaye, J, Kochan, NA, Lau, BHP, Lipnicki, DM, Lo, JW, Lucca, U, Makkar, SR, Marcon, G, Martin, P, Meguro, K, Milman, S, Poon, LW, Recchia, A, Ribeiro, O, Riva, E, Rott, C, Sikkes, SAM, Skoog, I, Stephan, B, Szewieczek, J, Teixeira, L, Tettamanti, M, Wilczyński, K & Sachdev, P 2022, 'Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies', Alzheimer's and Dementia. https://doi.org/10.1002/alz.12828

TY - JOUR

T1 - Cognition, function, and prevalent dementia in centenarians and near-centenarians

T2 - An individual participant data (IPD) meta-analysis of 18 studies

AU - Leung, Yvonne

AU - Barzilai, Nir

AU - Batko-Szwaczka, Agnieszka

AU - Beker, Nina

AU - Boerner, Kathrin

AU - Brayne, Carol

AU - Brodaty, Henry

AU - Cheung, Karen Siu Lan

AU - Corrada, María M.

AU - Crawford, John D.

AU - Galbussera, Alessia A.

AU - Gondo, Yasuyuki

AU - Holstege, Henne

AU - Hulsman, Marc

AU - Ishioka, Yoshiko Lily

AU - Jopp, Daniela

AU - Kawas, Claudia H.

AU - Kaye, Jeff

AU - Kochan, Nicole A.

AU - Lau, Bobo Hi Po

AU - Lipnicki, Darren M.

AU - Lo, Jessica W.

AU - Lucca, Ugo

AU - Makkar, Steve R.

AU - Marcon, Gabriella

AU - Martin, Peter

AU - Meguro, Kenichi

AU - Milman, Sofiya

AU - Poon, Leonard W.

AU - Recchia, Angela

AU - Ribeiro, Oscar

AU - Riva, Emma

AU - Rott, Christoph

AU - Sikkes, Sietske A.M.

AU - Skoog, Ingmar

AU - Stephan, Blossom

AU - Szewieczek, Jan

AU - Teixeira, Laetitia

AU - Tettamanti, Mauro

AU - Wilczyński, Krzysztof

AU - Sachdev, Perminder

N1 - Funding Information: The authors acknowledge the contribution of the late Professor Bo Hagberg from Lund University, who was a founding member of the international centenarian consortium and had offered invaluable data from the Swedish Centenarian Study for this paper. In addition, we wish to acknowledge the contribution of Dr Thomas Marlow from the University of Gothenburg, who was involved in data sharing and review of earlier drafts of this manuscript. We also thank Ms Catriona Daly, who is a former coordinator of the ICC‐Dementia, for her contribution to the early work on the consortium and this project. The funding was supported by NHMRC Australia program grant 1093083. Individual cohorts funded by local funding bodies. Funding Information: Governmental/charity support to individual researchers and/or the contributing studies: Nir Brazilai – Grants from the National Institutes of Health (P01AG021654), The Nathan Shock Center of Excellence for the basic Biology of Aging (P30AG038072). Batko‐Szwaczka Agnieszka, Jan Szewieczek & Krzysztof Wilczyński – The Polish Centenarian Study (PCS) was funded by the Medical University of Silesia, Katowice, Poland (grants NN‐2‐268/06, KNW‐2‐045/08, KNW‐2‐022/09) and by the National Science Centre, Poland (grant N 404535439) from the budget for science in years 2010‐2014. Henry Brodaty & Perminder Sachdev – supported by National Health & Medical Research Council of Australia. Karen Siu‐Lan Cheung & Bobo Hi‐Po Lau – The Hong Kong data were made available from the Hong Kong Centenarian Study (HKCS) that was supported by the Seed Funding Program for Basic Research, the matching fund from the Department of Social Work and Social Administration at University of Hong Kong (Project No. 104001032), and AXA funded red packets to the participants upon the completion of the interview. María M. Corrada – NIH grant R01AG021055 (to UCI). John Dudley Crawford & Darren Lipnicki‐ salary supported by NIH Grant No. 1RF1AG057531‐01. Jeffrey Kaye – supported by National Institutes of Health (NIA) P30AG066518 & Department of Veterans Affairs. Jessica W Lo – Salary supported by Vincent Fairfax Family Foundation. Peter Martin – supported by grant: NIH (1 PO1 AG17553‐01A1) & National Institute of Food and Agriculture (Hatch Project Grant, IOW04116). Sofiya Milman – supported by NIH, AFAR, and Glenn Foundation for Biomedical Research. Oscar Ribeiro & Laetitia Teixeira – The PT100 – Oporto Centenarian Study was supported by the Portuguese Foundation for Science and Technology (FCT; Grant Pest‐C/SAU/UI0688/2011 and C/SAU/UI0688/2014). Sietske Sikkes – supported by ZonMW, #7330502051, ZonMW, #73305095008, Health∼Holland, Topsector Life Sciences & Health (PPP‐allowance; #LSHM20084), Health∼Holland, Topsector Life Sciences & Health (#LSHM19051). Publisher Copyright: © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2022

Y1 - 2022

N2 - Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

AB - Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

KW - centenarians

KW - dementia

KW - education

KW - exceptional longevity

KW - prevalence

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85143900298&partnerID=8YFLogxK

U2 - 10.1002/alz.12828

DO - 10.1002/alz.12828

M3 - Article

C2 - 36453627

AN - SCOPUS:85143900298

SN - 1552-5260

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

ER -

Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Abstract

Keywords

Access to Document

Fingerprint

Cite this