Cocaine self-administration differentially alters mRNA expression of striatal peptides

Y. L. Hurd, E. E. Brown, J. M. Finlay, H. C. Fibiger, C. R. Gerfen

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

The influence of cocaine self-administration on the expression of messenger RNAs for dynorphin, enkephalin and substance P was analyzed in the rat striatum with in situ hybridization histochemistry. Cocaine, an indirect dopamine agonist, was found to differentially affect the levels of mRNA encoding these neuropeptides in different subregions of the striatum. Following a 7 day period of variable free access to cocaine, dynorphin and substance P mRNA levels were elevated throughout the striatum, but the increases were substantially greater in the dorsal striatum than in the nucleus accumbens. Enkephalin mRNA was not significantly altered in the dorsal striatum but was slightly elevated in the nucleus accumbens. These results suggest that cocaine self-administration has differential effects on striatonigral and striatopallidal projection neurons, and that these effects vary in subregions of the striatum.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalMolecular Brain Research
Volume13
Issue number1-2
DOIs
StatePublished - Mar 1992
Externally publishedYes

Keywords

  • Cocaine
  • Dopamine
  • Peptide
  • Striatum

Fingerprint

Dive into the research topics of 'Cocaine self-administration differentially alters mRNA expression of striatal peptides'. Together they form a unique fingerprint.

Cite this