CNS voltage-dependent Na+ channel expression and distribution in an undifferentiated and differentiated CNS cell line

David R. Castañeda-Castellanos, Mercedes Cano, James K.T. Wang, Adrian Corbett, Deanna Benson, Thomas J.J. Blanck, William B. Thornhill, Esperanza Recio-Pinto

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Upon serum removal, CAD-R1 cells undergo neurite outgrowth and an increase in voltage-dependent Na+ current (VDNaC) density without changing their activation and inactivation properties. Insulin and endothelial cell growth supplement inhibited the increase in VDNaC density but not the neurite outgrowth. RI, RII, RIII Na+ channel proteins were expressed in CAD-R1 cells. These proteins exhibited both similar and different distribution and clustering patterns which suggested the channel's structural differences play a role in channel distribution. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalBrain Research
Volume866
Issue number1-2
DOIs
StatePublished - 2 Jun 2000

Keywords

  • CAD-R1 cells
  • CNS cell line
  • Insulin
  • Sodium channel proteins
  • Targeting
  • Voltage-dependent sodium currents

Fingerprint

Dive into the research topics of 'CNS voltage-dependent Na+ channel expression and distribution in an undifferentiated and differentiated CNS cell line'. Together they form a unique fingerprint.

Cite this