Abstract
Upon serum removal, CAD-R1 cells undergo neurite outgrowth and an increase in voltage-dependent Na+ current (VDNaC) density without changing their activation and inactivation properties. Insulin and endothelial cell growth supplement inhibited the increase in VDNaC density but not the neurite outgrowth. RI, RII, RIII Na+ channel proteins were expressed in CAD-R1 cells. These proteins exhibited both similar and different distribution and clustering patterns which suggested the channel's structural differences play a role in channel distribution. Copyright (C) 2000 Elsevier Science B.V.
Original language | English |
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Pages (from-to) | 281-285 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 866 |
Issue number | 1-2 |
DOIs | |
State | Published - 2 Jun 2000 |
Keywords
- CAD-R1 cells
- CNS cell line
- Insulin
- Sodium channel proteins
- Targeting
- Voltage-dependent sodium currents