TY - JOUR
T1 - Close relation between lipoprotein (a) levels and atherothrombotic disease in Japanese subjects >75 years of age
AU - Kario, Kazuomi
AU - Matsuo, Takefumi
AU - Imiya, Masahiro
AU - Kayaba, Kazunori
AU - Kuroda, Toshio
AU - Nago, Naoki
AU - Matsuo, Hitoshi
AU - Shimada, Kazuyuki
N1 - Funding Information:
From the Department of Internal Medicine, Awaji-Hokutan Public Clinic and Hyogo Prefectural Awaji Hospital, Hyogo; the Department of Internal Medicine, Takasu Clinic, Gifu; and the Department of Cardiology and the Department of Community and Family Medicine, Jichi Medical School, Tochigi, Japan. This study was supported in part by grants-in-aid from the Foundation for the Development of the Community, Tochigi, Japan, the Japanese Medical Association, Hyogo, Japan, and the Japanese Ship Building Industry Foundation, Tokyo, Japan. Manuscript received July 13, 1993; revised manuscript received November 16, 1993, and accepted November 17.
PY - 1994/6/15
Y1 - 1994/6/15
N2 - Levels of lipoprotein (a) (Lp[a]) and various hemostatic factors were studied in 132 Japanese aged >75 years (mean 83). The group consisted of 50 healthy persons, 36 hypertensive subjects, 31 patients with chronic cerebral infarction, and 15 with coronary artery disease. Lp(a) levels were slightly lower in the healthy "old old" subjects than in the 184 healthy younger adults (mean ± SD: 10.7 ± 7.9 vs 12.1 ± 10.1 mg/dl). There were no gender-related differences in the Lp(a) levels of healthy adults and healthy old old subjects. Lp(a) levels were higher in the hypertensive old old subjects (14.6 ± 15.4 mg/dl) and the old old patients with cerebral infarction (21.3 ± 16.2 mg/dl) and coronary artery disease (26.5 ± 20.4 mg/dl). The prevalence of subjects with high Lp(a) levels (>30 mg/dl) was the greatest among old old patients with coronary artery disease (27%). Lp(a) levels in the 132 old old subjects showed positive correlations with sialic acid, fibrinogen, factor VII activity, and D-dimer levels. These results indicate a close association between Lp(a) levels and atherothrombotic disease as well as the characteristics of Lp(a) as an acute phase reactant in old old Japanese. Subjects with higher Lp(a) levels may develop cardiovascular disease later in life, whereas the remaining healthy old old subjects have lower Lp(a) levels.
AB - Levels of lipoprotein (a) (Lp[a]) and various hemostatic factors were studied in 132 Japanese aged >75 years (mean 83). The group consisted of 50 healthy persons, 36 hypertensive subjects, 31 patients with chronic cerebral infarction, and 15 with coronary artery disease. Lp(a) levels were slightly lower in the healthy "old old" subjects than in the 184 healthy younger adults (mean ± SD: 10.7 ± 7.9 vs 12.1 ± 10.1 mg/dl). There were no gender-related differences in the Lp(a) levels of healthy adults and healthy old old subjects. Lp(a) levels were higher in the hypertensive old old subjects (14.6 ± 15.4 mg/dl) and the old old patients with cerebral infarction (21.3 ± 16.2 mg/dl) and coronary artery disease (26.5 ± 20.4 mg/dl). The prevalence of subjects with high Lp(a) levels (>30 mg/dl) was the greatest among old old patients with coronary artery disease (27%). Lp(a) levels in the 132 old old subjects showed positive correlations with sialic acid, fibrinogen, factor VII activity, and D-dimer levels. These results indicate a close association between Lp(a) levels and atherothrombotic disease as well as the characteristics of Lp(a) as an acute phase reactant in old old Japanese. Subjects with higher Lp(a) levels may develop cardiovascular disease later in life, whereas the remaining healthy old old subjects have lower Lp(a) levels.
UR - http://www.scopus.com/inward/record.url?scp=0028356492&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(94)90179-1
DO - 10.1016/0002-9149(94)90179-1
M3 - Article
C2 - 8203336
AN - SCOPUS:0028356492
SN - 0002-9149
VL - 73
SP - 1187
EP - 1190
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 16
ER -