Cloning and chromosomal localization of the human BARX2 homeobox protein gene

Alan Krasner; Lalena Wallace; Arunthathi Thiagalingam; Christopher Jones; Christoph Lengauer; Lara Minahan; Yongkang Ma; Linda Kalikin; Andrew P. Feinberg; Ethylin Wang Jabs; Alan Tunnacliffe; Stephen B. Baylin; Douglas W. Ball; Barry D. Nelkin

doi:10.1016/S0378-1119(00)00169-4

Cloning and chromosomal localization of the human BARX2 homeobox protein gene

Alan Krasner, Lalena Wallace, Arunthathi Thiagalingam, Christopher Jones, Christoph Lengauer, Lara Minahan, Yongkang Ma, Linda Kalikin, Andrew P. Feinberg, Ethylin Wang Jabs, Alan Tunnacliffe, Stephen B. Baylin, Douglas W. Ball, Barry D. Nelkin

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY. BARX2 is highly expressed in adult salivary gland and is expressed at lower levels in other tissues, including mammary gland, kidney, and placenta. The BARX2 gene consists of four exons, and is located on human chromosome 11q25. This chromosomal location is within the minimal deletion region for Jacobsen syndrome, a syndrome including craniosynostosis and other developmental abnormalities. This chromosomal location, along with the reported expression of murine barx2 in craniofacial development, suggests that BARX2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	171-180
Number of pages	10
Journal	Gene
Volume	250
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(00)00169-4
State	Published - 30 May 2000
Externally published	Yes

Keywords

Chromosome 11
Jacobsen syndrome
Medullary thyroid carcinoma
Salivary gland

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10.1016/S0378-1119(00)00169-4

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title = "Cloning and chromosomal localization of the human BARX2 homeobox protein gene",

abstract = "The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY. BARX2 is highly expressed in adult salivary gland and is expressed at lower levels in other tissues, including mammary gland, kidney, and placenta. The BARX2 gene consists of four exons, and is located on human chromosome 11q25. This chromosomal location is within the minimal deletion region for Jacobsen syndrome, a syndrome including craniosynostosis and other developmental abnormalities. This chromosomal location, along with the reported expression of murine barx2 in craniofacial development, suggests that BARX2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome. (C) 2000 Elsevier Science B.V.",

keywords = "Chromosome 11, Jacobsen syndrome, Medullary thyroid carcinoma, Salivary gland",

author = "Alan Krasner and Lalena Wallace and Arunthathi Thiagalingam and Christopher Jones and Christoph Lengauer and Lara Minahan and Yongkang Ma and Linda Kalikin and Feinberg, {Andrew P.} and Jabs, {Ethylin Wang} and Alan Tunnacliffe and Baylin, {Stephen B.} and Ball, {Douglas W.} and Nelkin, {Barry D.}",

note = "Funding Information: A.K. and L.W. contributed equally to this work. This work was supported in part by National Cancer Institute Grant R01-CA47480 (B.D.N.). E.W.J. is supported by NIH Grant P50-DE11131. We thank Karen Stefanisko, William Paznekas and Val Hanson for excellent technical assistance.",

year = "2000",

month = may,

day = "30",

doi = "10.1016/S0378-1119(00)00169-4",

language = "English",

volume = "250",

pages = "171--180",

journal = "Gene",

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T1 - Cloning and chromosomal localization of the human BARX2 homeobox protein gene

AU - Krasner, Alan

AU - Wallace, Lalena

AU - Thiagalingam, Arunthathi

AU - Jones, Christopher

AU - Lengauer, Christoph

AU - Minahan, Lara

AU - Ma, Yongkang

AU - Kalikin, Linda

AU - Feinberg, Andrew P.

AU - Jabs, Ethylin Wang

AU - Tunnacliffe, Alan

AU - Baylin, Stephen B.

AU - Ball, Douglas W.

AU - Nelkin, Barry D.

N1 - Funding Information: A.K. and L.W. contributed equally to this work. This work was supported in part by National Cancer Institute Grant R01-CA47480 (B.D.N.). E.W.J. is supported by NIH Grant P50-DE11131. We thank Karen Stefanisko, William Paznekas and Val Hanson for excellent technical assistance.

PY - 2000/5/30

Y1 - 2000/5/30

N2 - The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY. BARX2 is highly expressed in adult salivary gland and is expressed at lower levels in other tissues, including mammary gland, kidney, and placenta. The BARX2 gene consists of four exons, and is located on human chromosome 11q25. This chromosomal location is within the minimal deletion region for Jacobsen syndrome, a syndrome including craniosynostosis and other developmental abnormalities. This chromosomal location, along with the reported expression of murine barx2 in craniofacial development, suggests that BARX2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome. (C) 2000 Elsevier Science B.V.

AB - The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY. BARX2 is highly expressed in adult salivary gland and is expressed at lower levels in other tissues, including mammary gland, kidney, and placenta. The BARX2 gene consists of four exons, and is located on human chromosome 11q25. This chromosomal location is within the minimal deletion region for Jacobsen syndrome, a syndrome including craniosynostosis and other developmental abnormalities. This chromosomal location, along with the reported expression of murine barx2 in craniofacial development, suggests that BARX2 may be causally involved in the craniofacial abnormalities in Jacobsen syndrome. (C) 2000 Elsevier Science B.V.

KW - Chromosome 11

KW - Jacobsen syndrome

KW - Medullary thyroid carcinoma

KW - Salivary gland

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DO - 10.1016/S0378-1119(00)00169-4

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AN - SCOPUS:0034732968

SN - 0378-1119

VL - 250

SP - 171

EP - 180

JO - Gene

JF - Gene

IS - 1-2

ER -

Cloning and chromosomal localization of the human BARX2 homeobox protein gene

Abstract

Keywords

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