Clonality analysis of childhood all in remission: No evidence of clonal hematopoiesis

Lambert Busque, Robert Ilaria, Ramana Tantravahi, Howard Weinstein, D. Gary Gilliland

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at the time of study and were excluded. We used the PGK-PCR clonality assay (PPCA) to analyze DNA from PMN and mononuclear cells of the remaining 29 female patients. All (29/29) patients demonstrated polyclonal hematopoiesis. These data show that remission from childhood ALL involves reestablishment of polyclonally derived hematopoiesis in all patients studied.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalLeukemia Research
Issue number2
StatePublished - Feb 1994
Externally publishedYes


  • Childhood acute lymphoblastic leukemia
  • PCR
  • PGK
  • clonality
  • cytogenetics


Dive into the research topics of 'Clonality analysis of childhood all in remission: No evidence of clonal hematopoiesis'. Together they form a unique fingerprint.

Cite this