Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications

Daniel I. Nathan, Max Dougherty, Manasa Bhatta, John Mascarenhas, Bridget K. Marcellino

Research output: Contribution to journalReview articlepeer-review

Abstract

Clonal hematopoiesis (CH) is defined by the presence of somatic mutations in hematopoietic stem and progenitor cells (HSPC). CH is associated primarily with advancing age and confers an elevated risk of progression to overt hematologic malignancy and cardiovascular disease. Increasingly, CH is associated with a wide range of diseases driven by, and sequelae of, inflammation. Accordingly, there is great interest in better understanding the pathophysiologic and clinical relationship between CH, aging, and disease. Both observational and experimental findings support the concept that CH is a potential common denominator in the inflammatory outcomes of aging. However, there is also evidence that local and systemic inflammatory states promote the growth and select for CH clones. In this review, we aim to provide an up-to-date summary of the nature of the relationship between inflammation and CH, which is central to unlocking potential therapeutic opportunities to prevent progression to myeloid malignancy.

Original languageEnglish
Article number104187
JournalCritical Reviews in Oncology/Hematology
Volume192
DOIs
StatePublished - Dec 2023

Keywords

  • Autoimmune disease
  • Cardiovascular disease
  • Clonal hematopoiesis
  • Hematologic malignancy
  • Inflammation
  • Myeloid neoplasm

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