TY - JOUR
T1 - Clomipramine Hydrochloride in Childhood and Adolescent Obsessive-Compulsive Disorder—a Multicenter Trial
AU - DEVEAUGH-GEISS, JOSEPH
AU - MOROZ, GEORGES
AU - BIEDERMAN, JOSEPH
AU - CANTWELL, DENNIS
AU - FONTAINE, REJEAN
AU - GREIST, JOHN H.
AU - REICHLER, ROBERT
AU - KATZ, RICHARD
AU - LANDAU, PHYLLIS
N1 - Funding Information:
The authors thank the co-investigators and other clinical study personnel at the five participating centers as well as the clinical research staffat Ciba-Geigy Corporation for their contribution to the conduct ofthis study. The study was supported in full by grantsfrom Ciba-Geigy Corporation, Ardsley, New York.
PY - 1992
Y1 - 1992
N2 - Children and adolescents with obsessive compulsive disorder were studied in an 8-week, multicenter, double-blind, parallel groups trial of clomipramine hydrochloride (CMI) versus placebo. Efficacy assessments included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global rating scale. At the end of 8 weeks, CMI-treated patients showed a mean reduction in Yale-Brown Obsessive Compulsive Scale score of 37% compared to 8% in the placebo group. Side effects were typical of tricyclic antidepressants. In a 1-year open label treatment, CMI continued to be effective and well tolerated. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:45–49.
AB - Children and adolescents with obsessive compulsive disorder were studied in an 8-week, multicenter, double-blind, parallel groups trial of clomipramine hydrochloride (CMI) versus placebo. Efficacy assessments included the child version of the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global rating scale. At the end of 8 weeks, CMI-treated patients showed a mean reduction in Yale-Brown Obsessive Compulsive Scale score of 37% compared to 8% in the placebo group. Side effects were typical of tricyclic antidepressants. In a 1-year open label treatment, CMI continued to be effective and well tolerated. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:45–49.
KW - Y-BOCS
KW - clomipramine
KW - compulsion
KW - obsession
KW - obsessive-compulsive disorder
UR - https://www.scopus.com/pages/publications/0026522443
U2 - 10.1097/00004583-199201000-00008
DO - 10.1097/00004583-199201000-00008
M3 - Article
C2 - 1537780
AN - SCOPUS:0026522443
SN - 0890-8567
VL - 31
SP - 45
EP - 49
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 1
ER -