TY - JOUR
T1 - Clobazam and diazepam in anxiety
AU - Rickels, Karl
AU - Brown, Avi S.
AU - Cohen, David
AU - Harris, Harvey
AU - Hurowitz, Aaron
AU - Lindenbaum, Ellis J.
AU - Ross, Harris A.
AU - Weinstock, Robert
AU - Wiseman, Kenneth
AU - Zal, Michael
PY - 1981/7
Y1 - 1981/7
N2 - The anxiolytic effects of clobazam, diazepam, and placebo were compared in a 4-wk double-blind study of 159 anxious outpatients, primarily from family practice. Clobazam (30 to 80 mg/day) and diazepam (15 to 40 mg/day) were found to induce similar side effects, primarily sedation, and although both active drugs induced greater clinical improvement than placebo, clobazam induced the largest degree of improvement in most aspects. It was speculated that the relatively high daily dosage of diazepam may have contributed to these results.
AB - The anxiolytic effects of clobazam, diazepam, and placebo were compared in a 4-wk double-blind study of 159 anxious outpatients, primarily from family practice. Clobazam (30 to 80 mg/day) and diazepam (15 to 40 mg/day) were found to induce similar side effects, primarily sedation, and although both active drugs induced greater clinical improvement than placebo, clobazam induced the largest degree of improvement in most aspects. It was speculated that the relatively high daily dosage of diazepam may have contributed to these results.
UR - http://www.scopus.com/inward/record.url?scp=0019442754&partnerID=8YFLogxK
U2 - 10.1038/clpt.1981.132
DO - 10.1038/clpt.1981.132
M3 - Article
C2 - 6113074
AN - SCOPUS:0019442754
SN - 0009-9236
VL - 30
SP - 95
EP - 100
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 1
ER -