Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Guilin Tang; Sa A. Wang; Victoria Lu; Hans Chulhee Lee; Muzaffar H. Qazilbash; Xiaohong I. Wang; C. Cameron Yin; Robert Orlowski; Yaping Wang; Ankita Patel; L. Jeffrey Medeiros; Gary Lu

doi:10.1016/j.leukres.2014.05.015

Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Guilin Tang
, Sa A. Wang
, Victoria Lu
, Hans Chulhee Lee
, Muzaffar H. Qazilbash
, Xiaohong I. Wang
, C. Cameron Yin
, Robert Orlowski
, Yaping Wang
, Ankita Patel
, L. Jeffrey Medeiros
, Gary Lu

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

Original language	English
Pages (from-to)	896-900
Number of pages	5
Journal	Leukemia Research
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2014.05.015
State	Published - Aug 2014
Externally published	Yes

Keywords

Bone marrow
Clonal cytogenetic abnormalities
Cytotoxic therapy
Silent
Therapy-related myeloid neoplasms

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10.1016/j.leukres.2014.05.015

Cite this

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title = "Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms",

abstract = "Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically {"}silent{"}. In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically {"}silent{"} CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.",

keywords = "Bone marrow, Clonal cytogenetic abnormalities, Cytotoxic therapy, Silent, Therapy-related myeloid neoplasms",

author = "Guilin Tang and Wang, \{Sa A.\} and Victoria Lu and Lee, \{Hans Chulhee\} and Qazilbash, \{Muzaffar H.\} and Wang, \{Xiaohong I.\} and Yin, \{C. Cameron\} and Robert Orlowski and Yaping Wang and Ankita Patel and Medeiros, \{L. Jeffrey\} and Gary Lu",

year = "2014",

month = aug,

doi = "10.1016/j.leukres.2014.05.015",

language = "English",

volume = "38",

pages = "896--900",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "8",

}

TY - JOUR

T1 - Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

AU - Tang, Guilin

AU - Wang, Sa A.

AU - Lu, Victoria

AU - Lee, Hans Chulhee

AU - Qazilbash, Muzaffar H.

AU - Wang, Xiaohong I.

AU - Yin, C. Cameron

AU - Orlowski, Robert

AU - Wang, Yaping

AU - Patel, Ankita

AU - Medeiros, L. Jeffrey

AU - Lu, Gary

PY - 2014/8

Y1 - 2014/8

N2 - Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

AB - Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.

KW - Bone marrow

KW - Clonal cytogenetic abnormalities

KW - Cytotoxic therapy

KW - Silent

KW - Therapy-related myeloid neoplasms

UR - https://www.scopus.com/pages/publications/84904550541

U2 - 10.1016/j.leukres.2014.05.015

DO - 10.1016/j.leukres.2014.05.015

M3 - Article

C2 - 24939217

AN - SCOPUS:84904550541

SN - 0145-2126

VL - 38

SP - 896

EP - 900

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms

Abstract

Keywords

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